Phytochemical 3,3'-Diindolylmethane, Protects Your Bone Against Osteoporosis

By Kyle J. Norton


Osteoporosis is a medical condition characterized by loss of bone density over time, caused by overexpression of bone loss compared to bone made.

In other words, osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time, leading to an increased risk of fracture. 

Most common fractures occurred in patients with OP are the hip, spine, wrist, and shoulder.
Most people with a risk of fracture do not know they have osteoporosis until the disease has advanced to the advanced stage.

Researchers do not know the exact causes of osteoporosis. Neither they know why some people with the same health condition in the same family, some are prone to the condition, while others do not.

However, according to the epidemiological studies, young age at diagnosis, male sex, aging, race, family history, body size, decreased lean mass, smoking and use of growth hormone replacement are some of the prevalent factors found in most patients with osteoporosis.

Most common symptoms of osteoporosis are lost of height over time, back pain, a stooped posture, neck, and low back pain, particularly bone break easily.

Recently, some scientists suggested that osteoporosis may also be associated with long term consumption of a poor diet.

Dr. Seon-Joo Park in the investigation of dietary patterns and osteoporosis risk wrote, "Three major dietary patterns were identified using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread)".

And, ".., Western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".

These results strongly suggested if you are Western diet follower, your risk of osteoporosis is increased substantially compared to other healthy diet pattern followers.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding the natural compound for the treatment of osteoporosis, researchers investigated the effect DIM on bone mass in mice under physiological and pathological conditions.

The study included 8-week-old female mice received injections of a vehicle or 0.1mg/g of DIM, twice a week for four weeks.

According to the dual-energy X-ray absorptiometry (DEXA) and micro-computed tomography (μCT) analysis, DIM treatment significantly increased bone mass.

Interestingly, treatment od DIM was found to significantly reduce bone resorption parameters but did not increase bone formation parameters.

In ovariectomized (OVX)-induced osteoporotic mouse model, administration of DIM effectively prevented OVX-induced bone loss resulting from increased bone resorption.

In other words, DIM increased bone mass by suppressing osteoclastic bone resorption in bone metabolism under both physiological and pathological conditions.

The results strongly suggested that DIM protect the bone integrity against the onset of osteoporosis in vivo and vitro.

Dr. Yu TY, the lead researcher, after taking other factors into account said, "DIM may be of value in the treatment and the possible prevention of bone diseases characterized by bone loss, such as postmenopausal osteoporosis".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic boneresorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PubMed)