Herbal Bilberry, the Best for the Prevention and treatment of Hyperglycemia, Human Study Reveal

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the treatment if hyperglycemia, according to studies.

Hyperglycemia is a condition of abnormally high blood glucose, a hallmark of diabetes. Another hallmark of diabetes is insulin resistance.

The condition is caused by insufficient insulin entered the bloodstream due to the gradual died off of beta cells in the pancreas or insulin receptors site clogged up by fat and cholesterol.

Type 1 diabetes is caused by immune autoimmune disease in which the immune system mistakenly attacks and destroys the beta cell in the pancreas, leading to insufficient numbers of beta cells which produce insulin.

As of today, researchers do not know what causes the immune system attacking the beta cells in the pancreas, either they do why some people with the same health condition, some are prone to the disease while others do not.

According to world statistics, the prevalences of diabetes are on the rise with no side of stopping. Among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014, it may be a result of economic expansion in the Southeast East where people have made more money and abandoned the traditional diet with more on fruits and vegetable.

The World Health Organization said, "The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014" and "Diabetes prevalence has been rising more rapidly in middle- and low-income countries".

The results strongly suggested that diabetes is a disease associated with a poor or unhealthy diet. In other words, people who follow the diet with a high amount of saturated and trans fat, a lot of red mead meats, processed foods and low amounts of fruits and vegetables are at a substantially higher risk of the disease onset.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a potential compound with no side effects for the treatment of abnormally high blood glucose, researchers investigated how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) compared to those of other berry diets associated with insulin and glucose metabolism.

The study included 47 individuals with metabolic syndrome randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12) for 8 weeks.

According to the LC-QTOF-MS metabolite profiling analysis, injection of BB showed a significant increase of fasting serum hippuric acid correlated with the improvement of fasting plasma glucose concentration and insulin secretion compared to other diet groups.

These improvements were associated with confirmation in the Finnish Diabetes Prevention Study (n = 198).

Additional differentiation of the bilberry antihyperglycemic activity, researchers found that the efficacy was attributed to the abundant anthocyanin in the bilberry fruits in stimulating the function of β-cells in the pancreas.

Dr. de Mello VD, the lead scientists said, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".

Furthermore, in vivo, male Wistar rats with STZ and HFD-induced diabetes fed with or without Vaccinium myrtillus L. leaf (VLE) or PCE for 50 days showed a significant effect on carbohydrate metabolism in diabetic rats.

According to the tested assays, 4 Of the 8 diabetic animals treated with bilberry leaf extract was found to have a normal HbA level. VLE group also showed a significant reduction in blood glucose level compared to the control of diabetic rats.

Dr. Sidorova, the lead scientist, after taking into account co and confounders said, "The set of results that were obtained in the present study reveals lipid-lowering and antioxidant action related to the administration of VLE and PCE in Wistar rats with diabetes, induced by STZ, in combination with a high-carbohydrate diet. VLE to a certain extent also reduced hyperglycemia in diabetic animals".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of hyperglycemia, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Hypoglycemic and hypolipidemic effect of Vaccinium myrtillus L. leaf and Phaseolus vulgaris L. seed coat extracts in diabetic rats by Sidorova Y1, Shipelin V2, Mazo V1, Zorin S1, Petrov N1, Kochetkova A. (PubMed)
(2) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)