Renal fibrosis is a condition of abnormal healing of the kidney tissues after injury, caused by the formation of scars in the kidney.
On finding a potential compound for the treatment of renal fibrosis, researchers examined the bioactive compound found in the fruits of Opuntia elatior Mill anti-oxidative and anti-inflammatory activity.
According to the previous study, oral administration of betanin exerted a protective effect against high glucose-induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN).
Finally, betanin protected the kidney against the onset of fibrosis by modulating the mRNA and function of protein expression associated with cellular differentiation, apoptosis, fibrogenesis, and network-forming collagen and tumor suppression against alternation of kidney cell DNA.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2. (PubMed)
(2) Fibrosis and renal aging by Hai-Chun Yang1 and Agnes B Fogo. (PMC)