Inflammation is a natural defense of the human body against the invasion of harmful microorganism.
With an aim to find a natural compound which processes anti-inflammatory property, researchers investigated cucurbitacin B (CuB) effect, a major compound found in cucumber on parameters related to antigen presentation and T-cell activation.
On basal and lipopolysaccharide (LPS)-induced inflammation, CuB inhibited significantly the LPS-a expression of MHC II (antigen-presenting cells), CD40, CD54, and CD80 associated with immunodeficiency with hyper-IgM.
In other to reveal more information anti-inflammatory activity of CuB, researchers evaluated the chemical ability to scavenge free radicals such as hydroxyl radical, superoxide anions and singlet oxygen.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages by Kim M1, Park SY1, Jin ML1, Park G1,2, Son HJ. (PubMed)
(2) Search for a novel antioxidant, anti- inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Saba, and . (Research Gate)
(3) Low-grade inflammation in chronic diseases: an integrative pathophysiology anticipated by homeopathy? by Adler UC. (PubMed)