Herbal Therapy: Andrographis in Reduced Risk and Treatment of Leukemia

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

A renowned institute study suggested that andrographolide, a major compound isolated from andrographis may consist a potentially therapeutic effects in reduced risk and controlling the progression of leukemia.

Leukemia is condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

According to the joint study lead by the Jining No 1 People's Hospital, andrographolide (Andro) showed to possess antitumor activities against T-cell acute lymphoblastic leukemia (T-ALL) through induced cytotoxicity in tumor and cell apoptosis.

10 μg/mL Andro could significantly induce tumor cells' death, depending on the inhibition of PI3K/AKT pathway in regulating the cell cycle and increased expression of cancer cell apoptosis.

Flavonoid, chemical compounds isolated from the aerial parts of Andrographis paniculata also exhibited antiproliferative effects against human leukaemia HL-60 cells with with IC50 of 3.50 μM.

Furthermore, the study in the evaluation of the potential effect of andrographolide against three acute promyelocytic leukaemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2,  andrographolide was 2- and 3-fold more active in inhibiting the growth of HL-60 and NB4-R2 cells compared with NB4 cells, through cell differentiating activity via a retinoic acid receptor-independent pathway.

In fact, according to Dr. Manikam SD, the lead researcher, andrographolide and its derivatives, apparently demonstrated a novel cell differentiating mechanism with ability to induce apoptosis.

There is no doubt that Andrographis with a novel mechanism of drug action may be a new candidated therapy for reduced risk and treatment of Leukemia, but large amount intake should be taken with care.

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Sources
(1) Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemiaJurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways by Yang T, Yao S, Zhang X, Guo Y.(PubMed)
(2) A new flavonoid from the aerial parts of Andrographis paniculata by Chen LX1, He H, Xia GY, Zhou KL, Qiu F.(PubMed)
(3) Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis by Manikam SD1, Stanslas J.(PubMed)