Monday, 18 September 2017

Food Therapy: High Coffee Consumption Increased Risk of Neural Tube Defects for Women with Alternated Gene CYP1A2

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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In compared to herbal medicine, food therapy even takes longerto ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of high amount of coffee and coffee caffeine during pregnancy may increased risk of infant
Neural Tube Defects, a renowned institute study suggested

Neural tube defects are prenatal defects of infants in related to the neuro system including the brain, spine, or spinal cord.

Coffee,  a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the study of total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002, returned questionnaire by participants showed a strong correlated between coffee and caffeine intake and risk of neural tube defect of spina bifida, But modestly increased risk of general NTDs and encephalocele.

More profoundly, in the reviewed literature in data base of PubMed, Springer Link and Elsevier databases up to August, 2014, out of a total of of six case-control studies and one cohort study,
The risk of neural tubal defects showed a relative odd ratio of 0.86 for total NTDs in pooled effect estimate of maternal coffee consumption during pregnancy, particular in the spina bifida subtype of NTD.

According the University of California women who carried alternated gene CYP1A2 (involved liver function in the metabolism of foreign substance entering to the body) with high amount of coffee and caffeine intake during pregnancy may also be associated to increased risk of neural tube defects (NTDs) due to increased oxidizer status.

In the self-reported coffee, tea, soda, and chocolate intake for mothers of 768 NTD cases, and 4143 controls delivered from 1997 to 2002. A subset of 306 NTD and 669 control infants and their parents with gene mutation, Mothers who consumed caffeine, bearing a mutation genes in oxidization, CYP1A2*1F quickly and acetylized NAT2 slowly had a non significantly elevated estimated risk for an NTD-affected pregnancy.

The risk of  neural tube defects was multiplied many times in women who carry the lone mutated gene CYP1A2*1F.

Taking altogether, pregnant women with high amount of coffee and coffee caffeine consumption may have a non significant risk to Neural Tube Defects and Sub types. But for women with genetic alternative gene CYP1A2*1F  should reduced intake of coffee with doctor recommendation during pregnancy.

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(1) Maternal caffeine consumption and risk of neural tube defects by Schmidt RJ1, Romitti PA, Burns TL, Browne ML, Druschel CM, Olney RS; National Birth Defects Prevention Study.(PubMed)
(2) Caffeine, selected metabolic gene variants, and risk for neural tube defects.
Schmidt RJ1, Romitti PA, Burns TL, Murray JC, Browne ML, Druschel CM, Olney RS; Nationa by Birth Defects Prevention Study(PubMed)

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