Herbal Therapy: Aloe Vera, The Immunomodulatory Whole Food Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Aloe Vera may be used as potential herbal medicine in enhanced immune function in promoted immunostimulatory and immunomodulatory expression.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating various diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

 Immunomodulatory effect is an action  involved regulation of immune system against invasion of foreign subjects in promoted infection and inflammation.

According to the joint study lead by the Sahlgrenska Academy at University of Gothenburg, oral administrated (AVH200®), an aloe vera extract modified the protein involved activation, proliferation and cytokine secretion of healthy human blood T cells, in a dose dependent manner.

Aloe-emodin(AE), a major constituent found in Aloe Vera exerted a positive effect in significantly enhanced dabrafenib (a BARF inhibitor) antiproliferative activity of mutant cell lines through immunomodulatory activity

The study also confirmed that AE possesses remarkable antineoplastic properties of drug(dabrafenib)  used in treatment of metastatic colon cancer, against melanoma cells.

In candida albicans, A. vera extract and its fractions on infected macrophages demonstrated an anti fungal effect through activated and modulated the immune response.

Furthermore, the extract also significantly increased cell viability of macrophages, in comparison with control group.

Additionally,  polysaccharide isolated from Aloe Vera explictly also enhanced immune function in producing specific antibody and inducing delayed hypersensitivity in mice model.

Collectively, chemical constituents found in Aloe vera have showed to exhibit immunomodulatory effects in regulated immune function against foreign invasion and allergic reactions and irregular cell growth, but further studies are necessary to confirm this validation.

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Sources
(1) Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro by Ahluwalia B1, Magnusson MK2, Isaksson S3, Larsson F4, Öhman L5.(PubMed)
(2) Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells by Tabolacci C1, Cordella M2, Turcano L3, Rossi S2, Lentini A3, Mariotti S4, Nisini R4, Sette G5, Eramo A2, Piredda L3, De Maria R5, Facchiano F6, Beninati S3.(PubMed)
(3) Immunomodulatory effects of Aloe vera and its fractions on response of macrophages against Candida albicans by Farahnejad Z1, Ghazanfari T, Yaraee R(PubMed)
(4) An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera by t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie RP.(PubMed)