Sunday, 3 September 2017

Food Therapy: Cruciferous Vegetables, the Best Natural Whole Food Medicine in Reduced risk Postprandial Metabolism

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment,  linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Postprandial metabolism is the chemical processes after eating, such as consumption of red meat is associated with an increased risk of cancer due to heat induced production of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), involved in the development of human carcinogen.

According to evaluation of the the effect of cruciferous vegetable consumption on the metabolism of PhIP in 20 non-smoking Caucasian male subjects, with three 12-day phase, intake of Cruciferous Vegetables increased the metabolism and synthesis of cholesterol, steroids and other lipids and inhibited levels of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) caused by intake of cooked red meat.

Dr. Walters DG, the lead author in the study said, " Cruciferous vegetable consumption significantly increased the urinary excretion of N(2)-hydroxy-PhIP-N(2)-glucuronide in 0-48 h urine samples to 127 and 136% of levels" and "cruciferous vegetable consumption can induce both the phase I and II metabolism of PhIP in humans"

In support of the above, in a three-period, dietary intervention study carried out with 20 non-smoking Caucasian male subjects consuming cooked meat meals containing known amounts of these carcinogens, the high cruciferous vegetable diet (250 g each of Brussels sprouts and broccoli per day) during period 2 reduced levels of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) and induced hepatic CYP1A2(metabolism and synthesis of cholesterol, steroids and other lipids) activity.

In fact, the examination of the after another 12 days without cruciferous vegetables consumption (period 3 of the study) levels of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) also was still reduced by 17 and 30%,.
This prolong response of metabolism of cruciferous vegetables may suggested that other enzymes may involve in reduced levels of PhIP,  instead of only metabolism and synthesis of cholesterol, steroids and other lipids.

Taking altogether, there is no doubt that intake of cruciferous vegetable may reduce levels of heat induced chemical agents in exhibition of cancers, particular in cancers caused by intake of cooked red meat.


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Sources
(1) Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans by Walters DG1, Young PJ, Agus C, Knize MG, Boobis AR, Gooderham NJ, Lake BG.(PubMed)
(2) Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man by Murray S1, Lake BG, Gray S, Edwards AJ, Springall C, Bowey EA, Williamson G, Boobis AR, Gooderham NJ.(PubMed)

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