Thursday, 10 August 2017

Herbal Therapy: Chaste Tree Berry Reduced Symptoms of Pain in Severe Primary Dysmenorrhea

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Chaste tree berry may have a potential effect in ameliorated the symptoms of severe uterine pain in women with primary dysmenorrhea.

Dysmenorrhea (painful menstruation) is a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the Nenehatun Hospital, In animal models, Chaste tree berry treatment significantly reduced symptoms of severe primary dysmenorrhea in the the end of third month of therapy.

In a total of total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) included in this study. 30 patients treated with ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 treated with Fructus agni casti (group 2) during three menstrual cycles using the visual analog scale (VAS) scores, pulsatility index (PI), herbal plant treated group showed a higher mean PI and RI values in patients with severe primary dysmenorrhea in compared control groups on the first day of the first menstrual cycle (P < 0.0001) but the means of both values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both),

Additionally, researchers also found an increased uterine blood flow but no significant differences in terms of Doppler findings between group 1 and 2, as women with severe symptoms of primary dysmenorrhea exhibited normally a high impedance to blood flow in uterine arteries with a preserved cyclic pattern throughout the whole cycle.

Dr. Aksoy AN, the lead author in the study said, "The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea"

Other researchers also insisted that the efficacy of Chaste tree berry in reduced pain may be associated to the antinociceptive and analgesic activities, according to the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds injection into mice study conducted by the Second Military Medical University.

More importantly, other member of the Vitex group such as Vitex doniana extract may also have an effect in reduced uterine pain through regulating the hormone production of prostaglandins, ergometrine and oxytocin which are found to have a direct involvement of uterine muscle contractions.

Taking together, Chaste tree berry  may be a potential herbal medicine for treatment of painful symptoms in women with severe primary dysmenorrhea involved many mechanisms, including the antinociceptive, analgesic, hormone regulated properties.

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(1) Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study by Aksoy AN1, Gözükara I, Kabil Kucur S.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)
(3) Activity of aqueous extract of the bark of Vitex doniana on uterine muscle response to drugs by Ladeji O1, Udoh FV, Okoye ZS.(PubMed)

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