Wednesday, 9 August 2017

Herbal Therapy, Chaste Tree Berry in Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Vitex agnus-castus fruit is found to process an anti irregular cell growth, the early stage of cancer development in colon, a university study suggested.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Colon cancer is a medical condition of the abnormal proliferation of cells in large intestine.

According to the Tokyo University of Pharmacy & Life Sciences, treatment with chaste tree berry induced apoptosis of cancer cells not by the presence of antioxidant but expression of anti body gene HO-1 in regulating oxidative stress.
Dr. Imai M, the lead researcher said. "Vitex treatment activates a pathway associated with HO-1 gene activation, resulting in the induction of apoptosis in COLO 201, (the colon cancer cell line)".

Additionally, in a novel strategy with biological approach for synthesis of silver nanoparticles (AgNPs), a toxic substance, using sodium para-hydroxybenzoate tetrahydrate (SPHT) isolated from Vitex negundo leaves, treatment of sodium para-hydroxybenzoate tetrahydrate (SPHT) improved the hydroxyl and carboxylic functional groups mediators in edhibited a stronger ability towards synthesis of AgNPs which indicated the apoptotic effect on human colon cancer cell lines.

The study also insisted that the extract displays a anti colon cancer activity confirmed by colorimetric assay, annexin V/Dead Cell Apoptosis and cell cycle analysis.

Furthermore, casticin, one of the major components of the fruits of chaste tree, showed a significantly induced apoptosic effect in of HT-29, HCT-116, SW480 and Caco-2 cells, reduced accumulation of reactive oxygen species (ROS) and increased the protein levels in regulation of cancer cell apoptosis and B-cell lymphoma activation of cell death of HT-29 cells, a colon cancer cell line.

Collectively, casticin also promoted Cell Death in cell division with the same mechanisms in other cancer cell lines, including HCT-116, SW480 and Caco-2 cells.

Taking together, chaste tree berry may be next therapeutic treatment for reduced risk and treatment of colon cancer, but injection of large quantity should only prescribed by related field specialists.

Back to Kyle J. Norton Home page

(1) Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: a potential natural anti-cancer substance by Imai M1, Kikuchi H, Denda T, Ohyama K, Hirobe C, Toyoda H.(PubMed)
(2) Synthesis and characterization of silver nanoparticles using crystal compound of sodium para-hydroxybenzoate tetrahydrate isolated from Vitex negundo. L leaves and its apoptotic effect on human colon cancer cell lines by Durai P1, Chinnasamy A2, Gajendran B1, Ramar M1, Pappu S3, Kasivelu G4, Thirunavukkarasu A5.(PubMed)
(3) Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells by Qu L1, Liu FX1, Cao XC2, Xiao Q2, Yang X2, Ren KQ2.(PubMed)