Saturday, 12 August 2017

Herbal Therapy: Aloe Vera, the Neuroprotective Natural Whole Food Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Study from renowned institute suggested that Aloe arborescens may be  a potentially neuroprotective
agent against copper induced neurobehavioral features of Parkinson's disease.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

According to the joint study lead by the Cadi Ayyad University, Neurosciences, Pharmacology and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated to neurological disorders, Parkinson's disease following Cu intoxication.

Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".

Aloe emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.

The study also insisted, the antioxidants activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).

In fact, The neuro protective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injure.

Taking together, Aloe Vera exerted neuroprotective effect in reduced risk of dementia through many aspects, including free radical inhibition, anti cytotoxicity, chemical toxicity..... but human trials are necessary to confirm its validity.

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(1) Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat by Abbaoui A1, Hiba OE2, Gamrani H3.(PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)