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Monday, 9 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Treatment In conventional medicine - Colchicine

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.


              


                                              Treatments

A. In conventional medicine perspective
2. Colchicine
a. Colchicine, used for a long period in gout, was approved for the first time in 2009 by the FDA for the prophylaxis and the treatment of acute attack, on the basis of a pivotal trial that showed the efficacy in the very short term – that is 24 h of a well-tolerated, low-dose regimen of Colcrys (colchicine, URL Pharma, Philadelphia, USA) to reduce pain in patients with acute gout – when given early(242). Use of medication should monitor through tapering, high-sensitivity CRP monitoring, bleeding risk and contraindications to ASA/NSAID therapy(244).
The main function of the medicine is to block the inflammatory processes and result in its utility for treating and preventing acute gout flare. Colchicine may also be used for treatment of other chronic inflammatory diseases involved the over expression of these molecular pathways(245).

b. Side effects are not limit to
1. Diarrhea
2. Dizziness
3. Flushing
4. Hair loss
5. Headache
6. Loss of appetite
7. Nausea; sore gums
8. Stomach pain
9. Vomiting
10. Etc.
According to the review of the research paper of "Thiocolchicoside: review of adverse effects" liver injury, pancreatitis, seizures, blood cell disorders, severe cutaneous disorders, rhabdomyolysis and reproductive disorders have been found in gout patients with the use of the medication(243).Long term usage of the medication also exhibited central nervous system (CNS) adverse effects(244).

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References 
(242) Effects of adrenocorticotropic hormone (ACTH) in gout, Author links open the overlay panel. Numbers correspond to the affiliation list which can be exposed by using the show more link by Alexander B. Gutman, M.D. 1, T.F. YĆ¼, M.D.(Science direct)
(243) Thiocolchicoside: review of adverse effects by [No authors listed](PubMed)
(244) Non-Steroidal Anti-Inflammatory Drugs and Aspirin Therapy for the Treatment of Acute and Recurrent Idiopathic Pericarditis by Schwier N1, Tran N2.(PubMed)
(245) Mechanism of action of colchicine in the treatment of gout by Dalbeth N1, Lauterio TJ2, Wolfe HR3.(PubMed)