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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).
Types of Musculo-Skeletal disorders in elder
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
7. Low back pain
Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.
A. In conventional medicine perspective
Acetaminophen is an analgesic drug used by conventional medicine for treatment of headaches, arthritis, etc., as well as reducing fever, often as an alternative to aspirin without causing gastrointestinal adverse effecta. Acetaminophen such as Tylenol can help to relive the pain of Gout.
b. Side effects if overdose, are not limit to
b.1. Nausea and vomiting
b.2. Appetite loss
b.6. Abdominal pain
The University of Adelaide, in a double-blind, placebo-controlled trial, showed that application of acetaminophen was associated with adverse effects of suppression of serum neutralizing antibody response and increased nasal symptoms and signs(233) and hepatic damage(234) and toxicity(234).
A.2. The study of Gout–what are the treatment options? indicated that The options available for the treatment of acute gout (236)are
a. NSAIDs, also known as nonsteroidal anti-inflammatory agents/analgesics are commonly prescribed to control gout attacks in patients with hyperuricaemia.
Colchicine, due to economic affordable to many patients has been prescribed for treatment of gout with less adverse effects such as better tolerated, especially in patients with peptic ulcer, gastrointestinal bleeding or dyspepsia or who are taking anticoagulants(237), in acute gout patients.
Dr. Bjarnason I, and the research team at King’s College School of Medicine and Dentistry, in the study of Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans, suggested "Ingested NSAIDs may cause a nonspecific colitis (in particular, fenemates), and many patients with collagenous colitis are taking NSAIDs. Large intestinal ulcers, bleeding, and perforation are occasionally due to NSAIDs. NSAIDs may cause relapse of classic inflammatory bowel disease and contribute to serious complications of diverticular disease (fistula and perforation)" and
"NSAIDs may occasionally cause small intestinal perforation, ulcers, and strictures requiring surgery. NSAIDs, however, frequently cause small intestinal inflammation, and the associated complications of blood loss and protein loss may lead to difficult management problems" and "The pathogenesis of NSAID enteropathy is a multistage process involving specific biochemical and subcellular organelle damage followed by a relatively nonspecific tissue reaction. The various possible treatments of NSAID-induced enteropathy (sulphasalazine, misoprostol, metronidazole) have yet to undergo rigorous trials"(239).
Dr. Davies NM and colleagues at the University of Sydney insisted, Non-steroidal anti-inflammatory drugs (NSAIDs) may also cause damage distal to the duodenum, through involving specific biochemical and subcellular organelle damage followed by inflammatory tissue reaction(240).
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