Thursday, 12 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Treatment In Herbal medicine - Artichoke

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.


In herbal medicine perspective
1. Artichoke
Apricot tree is classified with the family of the plum belongings to the family Rosaceae with yellow to orange color, often tinged red on the side exposed to the sun.
According to the University of Florida, Artichoke (Cynara scolymus L.) leaves historically used for the treatment of hyperuricemia and gout. In our study the leaves also inhibited the xanthine oxidase (XO) through the efficacy of caffeic acid derivatives and flavones(259) but not  luteolin, and luteolin 7-O-glucoside in animal study(259).
Dr. Caton SJ and colleagues at the joint study led by the University of Leeds, said, "Repeated exposure is known to enhance intake of a novel vegetable in early life but individual differences in response to familiarisation have emerged from recent studies"(260) learning to love artichoke may reduce risk of gout in aging process.
In fact, University of Tokushima study of caffeic acid insisted, The phenolic compounds ameliorated xanthine oxidase (XO) which which is related to several diseases, e.g. gout(262), through its antioxidant activity when comparison to the conventional allopurinol(261).
Further more the flavones found in artichoke exhibited anti xanthine oxidase and/or α-glucosidase effects by remarkedly lowered serum uric acid levels in potassium oxonate induced hyperuricemic mouse(263).

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(259) Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application by Sarawek S1, Feistel B, Pischel I, Butterweck V.(PubMed)
(260) Learning to eat vegetables in early life: the role of timing, age and individual eating traits by Caton SJ1, Blundell P2, Ahern SM2, Nekitsing C2, Olsen A3, Møller P3, Hausner H3, Remy E4, Nicklaus S4, Chabanet C4, Issanchou S4, Hetherington MM2.(PubMed)
(261) Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acid by Masuda T1, Shingai Y2, Takahashi C2, Inai M2, Miura Y2, Honda S2, Masuda A3.(PubMed)
(262) Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition by Chan WS1, Wen PC, Chiang HC.(PubMed)
(263) Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin by Su ZR1, Fan SY1, Shi WG1, Zhong BH2.(PubMed)

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