Tuesday, 10 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Treatment In conventional medicine - Corticosteroids

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.



A. In conventional medicine perspective
3. Corticosteroids
Corticosteroids, also known as terpod hormone, are an anti-inflammatory medicine prescribed for a wide range of conditions in reduced inflammation and suppressed the immune system.a. According to study, systemic corticosteroids could be used in severe poly articular flares(246). Anti-IL1 should provide a therapeutic alternative for severe cortico dependent gout with tophus(246). To prevent acute flares and reduce tophus volume, uric acid serum level should be reduced and maintained below 60mg/L (360╬╝mol/L). The medicine is also considered as one of most frequent prescription for treatment of gout patients(247).

b. Side effects are not limit to
b.1. Stomach irritation
b.2. Rapid heartbeat
b.3. Nausea
b.4. Insomnia
b.5. A metallic taste in the mouth
b.6. Etc.

According to the University of Alberta, application of glucocorticoids has shown to induce pressure in the cardiovascular system include dyslipidemia and hypertension(249) as well as exhibiting certain psychiatric symptoms, including depression(250) and psychiatric complications such as psychosis, mania, hypomania, depression, apathy, anxiety, panic, depersonalization, delirium, confusion, hallucinations, delusions, paranoia, cognitive impairment and dementia(251).
Dr. Mitra R said, "Glucocorticoid (GC) exposure is the most common etiology of drug-induced (secondary) osteoporosis." and "GC stimulates osteoclast-mediated bone resorption and reduces osteoblast-mediated bone formation, which results in increased overall net bone resorption'(248).

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(246) [Treatment of gout].[Article in French]by Dubost JJ1, Mathieu S, Soubrier M.(PubMed)
(247) Dual-Energy CT in Patients with Suspected Gouty Arthritis:: Effects on Treatment Regimen and Clinical Outcome by Metzger SC1, Koehm M2, Wichmann JL1, Buettner S3, Scholtz JE1, Beeres M1, Kerl JM1, Albrecht MH1, Hammerstingl R1, Vogl TJ1, Bauer RW4.(PubMed)
(248) Adverse effects of corticosteroids on bone metabolism: a review. by Mitra R1.(PubMed)
(249) Adverse effects of corticosteroids on the cardiovascular system by Sholter DE1, Armstrong PW.(PubMed)
(250) Psychiatric adverse effects of corticosteroids by Warrington TP1, Bostwick JM.(PubMed)
(251) Psychiatric complications of treatment with corticosteroids: review with case report by Kenna HA1, Poon AW, de los Angeles CP, Koran LM.(PubMed)

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