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Types of Musculo-Skeletal disorders in elder
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
7. Low back pain
Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
1. Oxidative stress
There are some evidences demonstrating that oxidative stress is associated to clinical symptoms in chronic pain syndrome of fibromyalgia(8), particular in lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma(9).
According to the Universidad de Sevilla, mitochondrial dysfunction is found to associated to the increased risk of fibromyalgia, probably due to CoQ10 deficiency in blood mononuclear cells(10).
In a total of 60 female study conduced by the King George's Medical University study, oxidative stress is a major cause of FMS. Moreover, the increased oxidative stress parameters are more strongly associated with severity of FMS.(11).
2. Chronic stress and psychological symptoms
The relationship between stress, depression and functionality seems to be part of a complex mechanism, which might affect the quality of life of patients with FM(12). According to the study led by the Universidade Federal de São Paulo, Stress index (96%), trait anxiety (over 50) and clinically relevant depression (greater than 20) are found in the female patient with FMS(13).
In spouses of sexually active reproductive women with fibromyalgia, Dr. Yener M and colleagues at the said, "FM can cause deterioration of emotional status and lead to sexual dysfunction" and "Also, psychological status could be affected in spouses of women with FM at reproductive age, and the severity of depression of their spouses was significantly correlated to that of women with FM"(14).
3. Alpha1-Antitrypsin (AAT)
There is a possible relationship between AAT deficiency (AAT-D) and fibromyalgia (FM) due to
inflammation(15). According to the Hospital Valle del Nalón, AAT replacement therapy has shown to induce a rapid, progressive, and constant control of their FM symptoms, in 2 Spanish sisters with alpha1-antitrypsin (AAT) deficiency and fibromyalgia (FM)(16).
4. Inflammatory rheumatic disorders
There is evidence to suggest that fibromyalgia occurs much more frequently than expected in
individuals with inflammatory rheumatic disorders(17). According to the cross-sectional study carried out in a hospital-based rheumatology unit. Standard clinical and laboratory data, FM patients with inflammatory and patients with non inflammatory rheumatic disorders, experience to fibromyalgic features dominate and become the main cause of morbidity(18).
Dr. Jiao J and colleagues at the joint study led by the China Academy of Chinese Medical Sciences, said, "FM patients with rheumatic diseases were found to have worse SF-36-assessed pain and physical health and less improvement in these measures following treatment from FTP than patients withoutrheumatic diseases. FM patients with rheumatic disease may require additional intervention to address underlying rheumatic disease-related limitations."(19).
5. Sleep disturbance
There is a reciprocal relationship exists between pain and sleep, and that intervention targeted primarily at insomnia may improve pain(20). According to the jopint study led by the Penn State College of Medicine, rates of CFS, FM or CFS + FM were high: 13% in SDB and 48% in insomnia. CFS occurred frequently in SDB and insomnia, but FM occurred frequently only in insomnia(21).
There is a report that low sleep quality has induced sexual dysfunction in female patients with fibromyalgia(22).
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(22) Effects of low sleep quality on sexual function, in women with fibromyalgia by Amasyali AS1, Taştaban E2, Amasyali SY3, Turan Y2, Kazan E1, Sari E4, Erol B5, Cengiz M6, Erol H1.(PubMed)