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Wednesday, 11 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Treatment In conventional medicine - Corticotrophin

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.


              


                                              Treatments

A. In conventional medicine perspective
4. Corticotrophin(Acortan, ACTH, Acthar, Acton, Cortigel, Trofocortina)
Acortan, ACTH, Acthar, Acton, Cortigel, Trofocortina are synthetic version of adrenocorticotropic hormone (ACTH), also known as corticotropin produced and secreted by the anterior pituitary gland used for treatment of gout in convention medicine with some success.the study of Dr. Alexander B. Gutman and Dr. YĆ¼, M.D suggested,  ACTH effected a very rapid and satisfactory response in the local and systemic manifestations of acute gout in seven of eleven cases treated, including one patient refractory to colchicine(252).
According to the University of Patras Medical School, ACTH injection. is effective and safe for the treatment of gout in hospitalized patients in replacement of problematicnon-steroidal anti-inflammatory drugs, steroids or colchicine in this patient population(253) for its better in management of gout and control of hyuperuricemia(254).

b. Side effects are not limit to
In the study of 162 children with infantile spasms were treated with ACTH at the Children’s Hospital, Helsinki, and at the Aurora Hospital, Helsinki, during 1960–76. In a large proportion (37%) of the children the treatment caused pronounced side effects, and the mortality was 4.9%.(255), such as hypertension, osteoporosis, hypokalaemic alkalosis, and other marked electrolyte disturbances.


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References
(252 Effects of adrenocorticotropic hormone (ACTH) in gout(Research Gate)
(253) ACTH as first line treatment for acute gout in 181 hospitalized patients by Daoussis D1, Antonopoulos I, Yiannopoulos G, Andonopoulos AP.(PubMed)
(254) Update on the management of hyperuricemia and gout by Pillinger MH1, Keenan RT.(PubMed)