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Monday, 16 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - Treatment in Herbal Medicine - Devil’s claw

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.


              


                                              Treatments


In herbal medicine perspective
4. Devil’s claw
Devil's claw also known as wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa,  used as herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.Harpagoside, a Glycoside, the chemical, principle extracted from the Devil’s Claw root, contributes the natural anti-inflammatory properties and used as a Gout remedy and other painful disorders of the musculoskeletal system(274). The major phytochemical harpagoside, as a major iridoid glycoside, exhibited anti-inflammatory and COX inhibitory activity against rheumatism, gout, palsy and amenorrhea(276), according to the National Institute of Pharmaceutical Education and Research.

According to the University of KwaZulu-Natal, Harpagophytum procumbens root may be very effective used in the management and/or control of painful, arthritic and other inflammatory conditions, as well as for adult-onset, type-2 diabetes mellitus as the roots is used exclusive in some communities of South Africa(275).
Furthermore, phytochemical phenylpropanoid glycoside acteoside found in the herb(277) also ameliorated the levels of serum uric acid and hyperuricemic in mice through expression of inhibited mouse liver xanthine dehydrogenase XDH and xanthine oxidase XO activity(278), the Second Military Medical University suggested.


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References
(274) Devils Claw as a Natural Remedy for Gout By: Betty Roberts
(275) Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract by Mahomed IM1, Ojewole JA.(PubMed)
(276) Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition by Gautam R1, Jachak SM, Saklani A.(PubMed)
(277) New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase by Boje K1, Lechtenberg M, Nahrstedt A.(PubMed)
(278) Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice by Huang CG1, Shang YJ, Zhang J, Zhang JR, Li WJ, Jiao BH.(PubMed)