Wednesday, 4 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Free radical scavengers Vitamin A

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

 The Antioxidants: The Free radical scavengers

 Dr. Choi HK in the study of dietary risk factors for rheumatic diseases said, "Because diet is an unavoidable universal exposure for people, even a small effect that can be achieved by dietary manipulation may produce a large impact on the population's health" and "A recent prospective study investigated several purported dietary factors for gout and confirmed some of the long-standing suspicions (red meats, seafood, beer, and liquor), exonerated others (total protein, wine, and purine-rich vegetables), and also identified potentially new protective factors (dairy products)"(185).

1. The Free radical scavengers
1.1. Vitamin A
Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin, which can not be stored in the live, converted from beta-carotene, a powerful antioxidant.
According to the Arthritis Research Centre of Canada, Vancouver, the finding of vitamin A and its derivative in reduced risk and treatment has been controversial as vitamin A supplementation and food fortification may contribute to the high frequency of hyperuricemia in the US population, whereas β-carotene intake may be beneficial against hyperuricemia(175) by using data from 14,349 participants ages ≥20 years in the Third National Health and Nutrition Examination Survey (1988-1994),
Dr. Ford ES and Dr. Choi HK, in the differentaition of the concentrations of uric acid with concentrations of vitamin A and beta-carotene among adults in the United States, said, "Concentrations of uric acid were significantly and positively associated with concentrations of vitamin A and inversely with concentrations of beta-carotene"(176), of that support the evaluation of the Vancouver finding.
In fact, there are several lines of indirect evidence implicate vitamin A intoxication, associated mainly with impaired renal function involved the inhibition of enzyme xanthine oxidase in ameliorated the conversion of xanthine to uric acid and vitamin A intoxication(177).

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References(175) Independent association of serum retinol and β-carotene levels with hyperuricemia: A national population study by Choi WJ1, Ford ES, Curhan G, Rankin JI, Choi HK(PubMed)
(176) Associations between concentrations of uric acid with concentrations of vitamin A and beta-carotene among adults in the United States by Ford ES1, Choi HK.(PubMed)
(177) Gout and vitamin A intoxication: is there a connection? by Mawson AR1, Onor GI.(PubMed)
(185) Dietary risk factors for rheumatic diseases by Choi HK1.(PubMed)

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