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Saturday, 7 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Free radical scavengers Vitamin C

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.



The Antioxidants: The Free radical scavengers

 Dr. Choi HK in the study of dietary risk factors for rheumatic diseases said, "Because diet is an unavoidable universal exposure for people, even a small effect that can be achieved by dietary manipulation may produce a large impact on the population's health" and "A recent prospective study investigated several purported dietary factors for gout and confirmed some of the long-standing suspicions (red meats, seafood, beer, and liquor), exonerated others (total protein, wine, and purine-rich vegetables), and also identified potentially new protective factors (dairy products)"(185).

1. The Free radical scavengers
1.2. Vitamin C
Vitamin C, also known as L-ascorbate is a water soluble vitamin with a chemical structure formula of C6H6O6. The vitamin cannot be stored in the body for more than 24 hours. Oral administration of vitamin C is associated to reduced risk of levels of serum uric acid (sUA) in chronic gout patients(178).
In fact, epidemiological evidence(180) has shown an support of the question of lifestyle and diet involved in significant role in gout and serum uric acid level which had been raised 2500 years ago, particular over intake of vitamin C(179).
A pilot randomized controlled trial involved patients with gout and an SU level >0.36 mmoles/liter (6 mg/dl), researchers at the University of Otago suggested that modest dosage of vitamin C (500 mg/day) for 8 weeks had no clinically significant urate-lowering effects in patients with gout of which differ from the findings in healthy control subjects with hyperuricemia(181) and contradicted to the study conducted by Johns Hopkins Bloomberg School of Public Health (vitamin C supplementation significantly lowered SUA, in reduced hyperuricemia or prevent incident and recurrent gout)(182).


(178) Dietary supplements for chronic gout by Andrés M1, Sivera F, Falzon L, Buchbinder R, Carmona L.(PubMed)
(179) The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout by Towiwat P1, Li ZG2.(PubMed)
(180) Epidemiology of gout by Roddy E1, Choi HK2.(PubMed)
(181) Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout: a pilot randomized controlled trial by Stamp LK1, O'Donnell JL, Frampton C, Drake JM, Zhang M, Chapman PT.(PubMed)
(182) Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials by Juraschek SP1, Miller ER 3rd, Gelber AC.(PubMed)
(185) Dietary risk factors for rheumatic diseases by Choi HK1.(PubMed)
(182) Polymorphisms in the vitamin D receptor and risk of gout in Chinese Han male population by Liu SG1, Li YY, Sun RX, Wang JL, Li XD, Han L, Chu N, Li CG.(PubMed)