Sunday, 8 May 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Free radical scavengers Vitamin D

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

               The Free radical scavengers

 Dr. Choi HK in the study of dietary risk factors for rheumatic diseases said, "Because diet is an unavoidable universal exposure for people, even a small effect that can be achieved by dietary manipulation may produce a large impact on the population's health" and "A recent prospective study investigated several purported dietary factors for gout and confirmed some of the long-standing suspicions (red meats, seafood, beer, and liquor), exonerated others (total protein, wine, and purine-rich vegetables), and also identified potentially new protective factors (dairy products)"(185).

1. The Free radical scavengers
1.3. Vitamin D
Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.
According to the The Affiliated Hospital of the Medical College, lower serum 25(OH)D levels is found to associated to patients with gout involved the attenuation of regulating immune system  in fighting against the inflammatory parameters(182)(183).
In fact, Dr. Takahashi S and colleagues at the Hyogo College of Medicine said, in the study of serum of concentrations of 1,25(OH)2-vitamin D3 in patients with gout, "The administration of uric acid lowering agent to the patients for 1 year caused a significant increase in their serum 1,25(OH)2-vitamin D3 concentration which was associated with a significant decrease in their serum uric acid concentration"(184).

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(183) Serum vitamin D and C-reactive protein levels are independently associated with diastolic dysfunction by Akin F1, Ayça B, Köse N, Celik O, Yilmaz Y, Akin MN, Arinc H, Ozkok A, Covic A, Kanbay M.(PubMed)
(184) Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout by Takahashi S1, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J, Higashino K.(PubMed)
(185) Dietary risk factors for rheumatic diseases by Choi HK1.(PubMed)

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