Turmeric Induces the Virally Infected Cancer Cells Death in Viro

By Kyle J. Norton

Cancer is a class of chronic diseases caused by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer start in the cell on the surface of the inner lining of specific tissue due to the alternation of cell  DNA. Overtime after colonizing the entire organ, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that use components of invaded cells to multiply, leading to the damages or alternation of the DNA or RNA of the host cells.

Most common types of virally infected cancer are
* Epstein-Barr virus (EBV) that spreads through saliva has been found to increase the risk of Burkitt lymphoma, some types of Hodgkin’s and non-Hodgkin’s lymphoma and stomach cancer.

* Hepatitis B virus (HBV) that spreads through infected blood, semen and other body fluids are found to induce cause of liver cancer.

* Hepatitis C virus (HCV) that spreads through infected blood has been found to cause liver cancer and non-Hodgkin’s lymphoma.

* Human immunodeficiency virus (HIV) that spreads through infected semen, vaginal fluids, blood, and breast milk is associated with Kaposi sarcoma, non-Hodgkin’s and Hodgkin’s lymphoma, and cervical cancer.

* Human herpesvirus 8 (HHV-8) has been a leading cause of Kaposi sarcoma in people who have a weakened immune system.

* Human papillomavirus (HPV) is known to cause cancer in men and women, including anal, cervical, penile, throat, vaginal and vulvar cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of infected cancer, researchers examined the effect of curcumin on human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines.

According to the tested assays, curcumin promoted cell cycle arrest by reducing the expression of cyclin D1 in the promotion of cancer, Cdk1 in cancer cell proliferation, and Cdc25C in cell DNA damage and apoptosis by reducing the expression of XIAP in poor prognosis marker and survivin in cancer cells survival.

Furthermore, the constitutive active NF-kappaB associated with cancer initiation, development, metastasis, and resistance in HTLV-I-infected T-cell lines was also suppressed by the administration of curcumin.

Moreover, curcumin-induced suppression of cHTLV-I-infected T-cell growth did not correlate with Tax expression level involved in antiapoptotic signals.

Based on the findings, Dr.Tomita M, the lead scientist wrote, "Curcumin inhibited the growth of HTLV-I-infected T-cell tumors implanted subcutaneously in SCID mice".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of virally infected cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines by Tomita M1, Matsuda T, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Ohshiro K, Mori N. (PubMed)
(2) Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells by Tomita M1, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N. (PubMed)
(3) 7 viruses that cause cancer by MD Anderson Cancer Center