Herbal Turmeric Exerts the Activity Similar to Cytostatic Drugs without Side Effects

By Kyle J. Norton

Cytostasis is the activity that inhibits cancer cell growth and multiplication.

Cytostatic drugs are medicines that inhibit cancer cell growth and division. Cytostatic drugs used in chemotherapy have been found to significant adverse effects.

Chemotherapy is a type of therapy that uses drugs to destroy cancer cells by keeping them from proliferation and migration.

Under normal circumstances, cell growth is a natural process. Every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells is back to a normal growth rate again.

Cancer cells are fast-growing cells ignored the cell cycle inhibitors that stop the cell from growing after certain cell cycle division compared to normal cells. 

According to the statistics provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes. In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

Conventionally, cytostatic drugs are powerful for the treatment of cancers.

The exact causes of cancer are unknown. Carcinoma accounting for over 90% of cancer diagnosed, is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands, including breast, prostate, lung, and colon.

Treatment of cancer conventionally is totally depending on types, grade and stage of cancer. Surgery, radiation and chemo drugs are used for the treatment in most cases of invasive cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer-associated with cytostatic drug resistance, researchers examined numerous adverse effects of mitoxantrone on drug-resistant tumors.

Curcumin, a plant-derived biomolecule isolated from Curcuma longa showed significant activity on the neoplastic and invasive potential of carcinosarcoma cells in vitro.

On the Walker-256 cells, curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone.

However, curcumin only strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells tin a long-term mitoxantrone/curcumin treatment.

Based on the findings, curcumin only reduced the effective doses of mitoxantrone but also inhibits the invasive potential of drug-resistant carcinosarcoma cells.

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for reducing the side effects of chemo drug, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro by Luty M1, Kwiecień E1, Firlej M2, Łabędź-Masłowska A1, Paw M1, Madeja Z1, Czyż J. (PubMed)