Thursday, 16 January 2020

Lycopene Protects the Lung Against Injury

By Kyle J. Norton

The lungs are a pair of spongy, air-filled organs located on either side of the chest with the main function to process of gas exchange during breathing.

In other words, lung transfers life-giving oxygen into the blood supply and removes carbon dioxide produced by cells metabolism from the blood.

The lung is also the first-line defense against inhaled particles and prevent the circulation of emboli such as blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), or foreign material.

The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.

Additonally, the lung also processes other ability in protecting our body against disease, including balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body. 

Any part of the lung injury can reduce the lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the treatment of lung disease researchers examined the protective effects of Sarcandra glabra combined with lycopene against lung injury (ALI) in an animal model.

Administration of Sarcandra glabra combined with lycopene in rats induced acute injury included by LPS in the study showed a significant effect on improving anti-oxidative activities.

Furthermore, the combination also decreased the expression of pro-inflammatory proteins including TNF-α and IL-6, by suppressing the activations of factors that cause the production of cytokines.

Additionally, abnormal metabolism induced by LPS was also reversed by the injection of the combination.

Based on the findings, researchers said, " this integrated study revealed that Sarcandra glabra combined with lycopene had great potential in protecting rats from LPS-induced ALI, which would be helpful to guide the clinical medication".

Taken altogether, lycopene used alone or combined with Sarcandra glabra may be considered a remedy for the prevention and treatment of acute lung injury, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Sarcandra glabra combined with lycopene protects rats from lipopolysaccharide-induced acute lung injury via reducing inflammatory response by Liu TY1, Chen SB. (PubMed)
(2) Effects of Lycopene in Hyperoxia-Induced Lung Injury in Newborn Rats by Bastug O1, Fatih Sonmez M2, Ozturk MA1, Korkmaz L1, Kesici H3, Cilenk KT2, Halis H1, Korkut S1, Ozdemir A1, Bastug F4, Gunes T1, Kurtoglu S. (PubMed)

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