Lycopene Reduces Risk and Treatment of Kidney Cancer in Vivo

By Kyle J. Norton

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potent compound for the treatment of kidney cancer, researchers examined the effects of lycopene on renal cell carcinoma (RCC) associated with frequent upper urinary tract cancer in humans, accounting for 80-85% of malignant renal tumors.

The study included  10 weeks old Eker rat, the unique animal model to study RCC induced spontaneous renal tumors with a genetic mutation of TSC2 received 0, 100 or 200mg/kg of lycopene as part of their daily diet for 18 months.

According to the tested analysis associated with tumors counted measured in individual kidneys, lycopene treated group showed a decrease of 94% of tumor counts compared to 65% in the control group.

The mean numbers of renal carcinomas in the treated group were statistically significantly decreased compared to untreated controls.

Furthermore, the decrease of tumor counts in the lycopene was linearly depending on the concentration of the phytochemical observed by the increase of the supplement from 0 to 200 mg/kg.

Moreover, compared to control rats fed an only basal diet with a greater length of tumors (23.98 mm)compared to rats fed lycopene supplement with the length of 12.90 mm and 11.07 mm at the concentration 0 to 200mg/kg respectively.

The results of this efficacy were attributed to lycopene in the promotion of antibodies against proteins mTOR associated with cell proliferation and cancer progression and phospho-S6 protein associated with predicts unfavorable clinical survival and epidermal growth factor receptor (EGFR) in the promotion of solid tumor growth.

Collectively, researchers said, "dietary supplementation with lycopene attenuates the development of renal cell cancers in the predisposed TSC2 mutant Eker rat model:,

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of kidney cancer pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model by Sahin K1, Cross B2, Sahin N1, Ciccone K2, Suleiman S2, Osunkoya AO2, Master V2, Harris W2, Carthon B2, Mohammad R3, Bilir B2, Wertz K4, Moreno CS2, Walker CL5, Kucuk O. (PubMed)