Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : June 2019

Sunday, 30 June 2019

Herbal Bilberry, the Natural Treatment for Varicose Veins with No Side Effects

By Kyle J. Norton

Varicose veins are the medical condition in which the superficial veins have become enlarged and twisted.

The condition has been found to induce bleeding or superficial thrombophlebitis if left untreated.

Most common causes of varicose veins are found just under the skin in the legs, leading to the symptoms of fullness and pain in the affected location accompanied by symptoms of achy or heavy feeling in the legs. The pain is also worsened after a long time of sitting or standing for a long time and skin discoloration around the area.

Some patients with painful varicose veins also experience symptoms of burning, throbbing, muscle cramping and swelling in the lower legs and itching.

Out of many risk factors associated with the onset of varicose veins, aging due to wear and tear on the valves in the veins that help regulate blood flow may be one of the most common risk factors.

Dr. Caggiati A in the study of age-related variations of varicose veins, wrote, "Varicose SVs were more frequent in the older group (62%) than in younger one (39%) owing to a higher prevalence of limbs with combined saphenous veins (SVs) and Stributaries of the SVs (STVs) varicosities (respectively, 59% and 37%)".

And, "varicose disease may progressively extend in an antegrade fashion, spreading from the STVs to the SVs".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural ingredient for the treatment of varicose veins and chronic venous insufficiency (CVI), researchers compared the efficacy of Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) against the therapeutic compressions.

The study included 1,051 patients who completed the registry. During the experiment, there are no safety or tolerability problems observed.

Mirtoselect (bilberry) showed a significant effect on skin flux but in a lesser extent compared to those of Venoruton, Pycnogenol, and the combination VE-PY.

The edema score was decreased more effectively with the combination and with Pycnogenol compared to the other treatment group including the Mirtoselect (bilberry).

According to the improvement in symptoms score, Pycnogenol and compression showed a larger decrease in oxidative stress compared to the Pycnogenol, Venoruton, Mirtoselect (bilberry) and with the VE-PY combination.

However, the efficacy of Pycnogenol and the combination are competitive with stockings that do not have the same tolerability in warmer climates compared to other groups.

The findings suggested that the tested compounds processed anti chronic venous insufficiency (CVI) and varicose veins properties.

Taken altogether, Mirtoselect (bilberry) may be considered a functioning remedy for the treatment of varicose veins with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings by Belcaro G1, Dugall M1, Luzzi R1, Corsi M1, Ledda A1, Ricci A1, Pellegrini L1, Cesarone MR1, Hosoi M1, Errichi BM1, Cornelli U1, Cotellese R1, Agus G1, Feragalli B. (PubMed)
(2) Age-related variations of varicose veins anatomy by Caggiati A1, Rosi C, Heyn R, Franceschini M, Acconcia MC. (PubMed)

Phytochemical Alliin the Anti Liver Cancer Bioactive Ingredient

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue.

According to the statistics assessed by the cancer experts, in 2019, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.

Most common preventable causes of liver cancer are excessive alcohol drinking over time, chronic infection by hepatitis B and C, and cirrhosis.

Types of liver cancer include

* Hepatocellular carcinoma, the most common type of liver cancer accounting for 75 percent of all cases.

* Cholangiocarcinoma is a cancer of the bile duct, which is the small, tube-like bile ducts in the liver that carry bile to the gallbladder to help with digestion.

* Liver Angiosarcoma is a rare form of liver cancer that develops quickly and

* Hepatoblastoma also is a rare type of liver cancer found in children, particularly in those under age 3.

Most common symptoms of liver cancer are upper abdominal pain., abdominal swelling, jaundice and white, chalky stools, accompanied by general symptoms shared by other types of cancer including unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.

If you have experienced some of the aforementioned symptoms with no signs of receding, please make sure that you check with your doctor to rule out the possibility.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the treatment of liver cancer with little or no side effects, researchers in the cancer team at the Institut National de la Recherche Agronomique examined the increasing fertilization of soil resulted in an increased alliin content of the powders on liver cancer animal model.

According to the results, garlic powders administered to rats for 2 weeks (5% of the diet), administration of the different garlic powders demonstrated a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

In examining the increased alliin content of the garlic powder, researchers found that the presence of alliin was associated strongly with a proportional decrease in NDMA induced DNA alteration.

Believe it or not, the increased levels of alliin in the garlic powder content did not have additional effect in DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon, compared the efficacy in the liver.

In other words, garlic powders regardless of the levels of alliin did not modify the genotoxic activity which is the direct-acting carcinogen methylnitrosourea in the colon.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of liver cancer, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats by Le Bon AM1, Vernevaut MF, Guenot L, Kahane R, Auger J, Arnault I, Haffner T, Siess MH.(PubMed)

Navy Bean, Ameliorates Glycemic Stress of Diabetes in VIvo

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common forms of Diabetes are

* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. Most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body metabolized glucose. In other words, most cases of type 2 diabetes are results of insulin receptors clogged-up by fat and cholesterol, leading to resist the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

Most common symptoms of diabetes are excessive thirst and hunger, frequent urination, unintended weight loss or gain, frequent fatigue, irritability and gastrointestinal symptoms such as nausea.

In severe case, patients may also experience symptoms of blurred vision and slow wound healing or ulcer.

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. The bean is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find a potential compound for the management of diabetes, researchers investigated that the effect on glucose response of navy bean flour prepared as unleavened bread.

According to the tested assays

* Removal of phytic acid and addition of Ca to navy bean flour increased the starch digestion in vitro and raised the glycemic response

* However, readdition of phytic acid to dephytinized flour produced the opposite effect, in vivo.

In other words, phytic acid found in navy bean increased the slow digestion of navy bean that benefits the management of diabetes and hyperlipidemia.

Also, according to the carbohydrate malabsorption assessed by breath H2 measurement, phytic acid has a strong influence related negatively to glycemic response.

Based on the findings, researchers said, " role of both added and endogenous phytic acid in slowing the in vitro rate of starch digestibility and in vivo glycemic response to legumes and the ability of Ca modify this effect".

Additionally, Dr. Hutchins AM, the lead scientists in the examined the effect of beans consumption such as pinto, black, navy or kidney in the prevention and treatment of chronic diseases suggested that

* Dietary beans reduced the glycemic stress such as hyperglycemia and hyperinsulinemia in patients with diabetes, CVD and cancer.

* Patients who eat more of these beans improved the glycaemic response and reduced the risk of developing diabetes, CVD and cancer.

Taken altogether, navy bean used alone or combined with conventional medicine may be considered a remedy for the management of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Phytic acid and calcium affect the in vitro rate of navy bean starch digestion and blood glucose response in humans by Thompson LU, Button CL, Jenkins DJ. (PubMed)
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)
(3) Diabetes – The Symptoms by Kyle J. Norton

Herbal Turmeric, the Potent Anti Facial Skin-Aging Functional Remedy

By Kyle J. Norton

Facial aging is a biological process caused by the structural rearrangements on the face, uneven fat distribution in the face, leading to wrinkles and pockets plumped up the forehead, temples, cheeks, and areas around the eyes and mouth.

Aging caused by the gravity, fats that support the firming of the face loses volume, clumps up, and shifts downward accompanied by the natural degeneration of the skin can also contribute to facial aging.

Also, the facial muscles continually tug on, leading to the formation of facial wrinkle.

Besides aging, wrinkles may be caused by long-term exposure to the sun by smoking.

However, in North America, the wrong perception of sun exposure is one of the extrinsic factors that add burden to natural facial aging.

Dr. Frederic Flament, wrote, "During a lifetime, skin will change in appearance and structure not only because of chronological and intrinsic processes but also due to several external factors such as gravity, sun and ultraviolet exposure, and high levels of pollution; or lifestyle factors that have important and obvious effects on skin aging, such as diet, tobacco, illness, or stress".

And, "Clinical signs of aging are essentially influenced by extrinsic factors, especially sun exposure. Indeed UV exposure seems to be responsible for 80% of visible facial aging signs".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a better compound for the treatment of facial photoaging, researchers examined curcumin, the main ingredient from turmeric and turmeric extract in the promotion of healthy skin and inhibition of wrinkle formation caused by exposure to UV radiation.

According to the tested assays, curcumin exerted the strong effect on the deposition of basement membrane component at dermal-epidermal junction in the skin equivalent model.

Topical application of a cream containing turmeric extract in UV radiation-induced facial photoaging significantly improved facial skin elasticity and decreased the number of gelatinase-positive stratum corneum clusters in human facial skins.

Based on the results, researchers wrote in the final report, "These results indicated that turmeric is an effective ingredient to improve skin condition and to prevent skin from photoaging by suppressing activation of gelatinase chronically caused by UV".

In chronic ultraviolet B (UVB)-irradiated skin damage in melanin-possessing hairless mice, turmeric extract improved the skin thickness and elasticity caused by long-term, low-dose ultraviolet B irradiation at 300 or 1000 mg/kg, applied twice daily.

Furthermore, at 1000 mg/kg, applied twice daily, the extract also prevented the formation of wrinkles and melanin and diameter and length of skin blood vessels and the expression of the enzyme (matrix metalloproteinase-2 (MMP-2)) in the inhibition of elastin, a highly elastic protein in the production of connective tissue.

Dr. Sumiyoshi M. the lead scientist after taking other factors into account wrote, "(Turmeric extract) Prevention of UVB-induced skin aging by turmeric may be due to the inhibition of increases in MMP-2 expression caused by chronic irradiation"

Taken altogether, turmeric in form of extract may be considered supplements for the prevention and treatment of facial photoaging, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect of the extract of rhizome of Curcuma longa L in gelatinase activity and its effect on human skin by Muta K1, Inomata S2, Fukuhara T2, Nomura J2, Nishiyama T3, Tagawa YI4, Amano S2. (PubMed)
(2) Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice by Sumiyoshi M1, Kimura Y. (PubMed)
(3) Effect of the sun on visible clinical signs of aging in Caucasian skin by Frederic Flament,1 Roland Bazin,2 Sabine Laquieze,3 Virginie Rubert,1 Elisa Simonpietri,4and Bertrand Piot. (PMC)

Phytochemical Betacyanins Inhibits Breast Cancer Cells Initiation and Progression

By Kyle J. Norton

The breasts of women are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman breast is totally depending on the amount of fat in the breast.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA.

Most cases of breast cancer start in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk, before colonizing the deeper layer tissues to form a tumor through proliferation.

According to the statistics, in the US, the lifetime the risk of getting invasive breast cancer of a woman is 1/8. In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed, along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.

The exact causes of breast cancer are not identified.

The stages of breast cancer can be classified depending on
* The size of the cancer
* Invasive or not
* Whether cancer has spread to the lymph nodes
* Whether cancer has spread to the distance parts or organs of the body.

There are 4 stages of breast cancer in TNM rating (where T is referred for tumor size, N is referred for Lymph Node status, M is referred for invasive or not)
# T: Tumor Size is divided into four classes: T-1 is between 0 - 2 cms, T-2 is between 2 - 5 cms, T-3 is > 5cms, and T-4 is a tumor of any size growing into the chest wall or skin, including inflammatory breast cancer.
#N: No swollen nodes: N-0, some swelling but negative node (not cancerous): N-1a, swelling nodes and positive node (cancerous): N-1b, quite swollen and bunched together: N-2, quite swollen and near the collarbone: N-3.
# M: if no cancer cell is found: M-0, cancer cells found: M-1.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, chard, etc.

On finding a potential compound for the treatment of breast cancer, researchers examined the effect of extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162 on estrogen receptor-positive human breast cancer cells (MCF-7).

According to the tested differentiation, both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in MCF-7.

Compared to doxorubicin, the cytotoxicity of beetroot extract was significantly lower.

In other words, at the same doses, doxorubicin is more effective to induce the death of breast cancer cell compared to the beetroot extract.

Due to the limitation of the experimental selection, side effects induced by both treatment cannot be observed.

After taking other factors into account, researchers suggested, the major betacyanin constituent may play an important role in the cytotoxicity exhibited by the red beetroot extract.

Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Breast #Cancer by Kyle J. Norton

Saturday, 29 June 2019

Phytochemical Betanin, the Potent Antioxidant

By Kyle J. Norton

Antioxidants are stable atoms which inhibit oxidation induced by free radicals.

There are 2 types of antioxidants found in the human body, including

* Internally, antioxidant enzymes produced by the liver

* Externally, antioxidants produced by the intake of antioxidants rich food.

Free radicals, in fact, are everywhere, any atoms with oxygen molecules that have an unpaired electron on the outermost ring are considered free radicals.

Free radicals are unstable atoms. Therefore, in order to maintain stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain of reaction which can not be stopped until all outermost ring electrons are paired or inhibited by antioxidant.

An unbalanced ratio of the levels of free radicals and antioxidants over the long-term can induce oxidative stress, a condition that causes protein and lipid damage and alternation of cell DNA.

In a healthy individual, antioxidants produced by the body are normally good enough to neutralize by free radical produced by the body in support cellular metabolism and by external sources, such as the air we breathe and the foods we eat.

Diseases associated with oxidative stress including cardiovascular disease, type II diabetes and cancer.

However, for people with a weakened immune system such as elderly, intake of antioxidants may be necessary.

Dr. wrote, "Oxidant-mediated tissue injury is a particular hazard to the immune system since phagocytic cells produce reactive oxygen species as part of the body's defense against infection".

And, " Although more striking effects have been observed in the elderly, there is also evidence that antioxidant nutrients can modify cell-mediated immune responses in younger individuals".

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound associated with the reduced risk of oxidative stress, researchers examined the antioxidant activity of betanin on a rat paraquat-induced acute lung injury (ALI) model.

The study included paraquat injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) following the orally administered 3 days before and 2 days after paraquat administration in selected rats.

According to the results by tested assays on rats sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) collected, rats treated only with paraquat showed an extensive lung injury characteristic of ALI, including increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels, lung oxidative stress markers, reduced antioxidant activity and increased expression of pro-inflammatory proteins in the lung.

Rat treated with betanin attenuated all such changes, in a dose-dependent manner.

In other words, betanin ameliorated the effects of paraquat-induced ALI probably via antioxidant and anti-inflammatory mechanisms.

In order to maintain the release of betanin, researchers incorporated red beetroot (RB) powder was into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties.

According to free radical assays, betanin released by the corporation demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)) compared to the application of red beetroot (RB) powder.

More precisely, red beetroot (RB) powder incorporated into starch-based bio-elastomers is more effective to inhibit oxidation caused by free radicals compared to red beetroot (RB) powder.

Based on the results, Dr. Tran TN, the lead scientist wrote, "Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used (to provide antioxidation) in active packaging for a variety of pharmaceutical, medical, and food applications".

Taken altogether, betanin may be considered supplements to improve the antioxidant profile of patients, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia by Han J1, Ma D1, Zhang M1, Yang X1, Tan D. (PubMed)
(2) Starch-based bio-elastomers functionalized with red beetroot natural antioxidant by Tran TN1, Athanassiou A2, Basit A3, Bayer IS. (PubMed)
(3) Effects of dietary antioxidants on the immune function of middle-aged adults by Hughes DA. (PubMed)

Herbal Turmeric Processes the Lung Protective Against Respiratory Diseases in Vitro and Vivo

By Kyle J. Norton

Lung protection is an action in which substances, including herbal remedies, are used to protect the lung against injury or damage.

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Symptoms of lung disease are totally depending on the type of disease.

Out of many risk factors, occupational lung diseases are one of the most challenging in the modern world.

Dr. Sara De Matteis, the lead scientist wrote, "New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects".

And, "In addition, the aging workforce, many of whom have pre-existing respiratory conditions, poses new challenges in terms of the diagnosis and management of occupational lung diseases".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

On finding a potential compound which processes respiratory protective effects, researchers examined the anti-inflammatory properties through down-regulating inflammatory cytokines of curcumin on acute lung injury in mouse peritoneal macrophages by ELISA.

All 30 curcumin analogs included in the study. the bioactive ingredient showed a strong effect in the inhibition of production of proinflammatory cytokines (TNF-α and IL-6) induced by the injection of LPS.

In vitro, some compound exhibited anti-inflammatory activity in a dose-dependent manner and greater stability compared to that of curcumin.

In vivo, SD rats pretreatment with a curcumin analog (c26) for seven days and then intratracheally injected with LPS to induce acute lung injury (ALI) was found to inhibit the increased protein concentration and number of inflammatory cells, pathological changes of lung tissue, inflammatory cytokines in serum and inflammatory gene expression caused by LPS.

Compared to another curcumin analog, c26 has remarkable protective effects on LPS-induced ALI in rats.

In other words, the efficacy of curcumin against acute lung injury was associated with the presence of component c26.

Taken altogether, turmeric may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury by Zhang Y1, Liang D2, Dong L3, Ge X4, Xu F5, Chen W6, Dai Y7, Li H8, Zou P9, Yang S10, Liang G. (PubMed)
(2) Curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex I activity, and membrane permeability transition pore opening by García-Niño WR1, Tapia E, Zazueta C, Zatarain-Barrón ZL, Hernández-Pando R, Vega-García CC, Pedraza-Chaverrí J. (PubMed)
(3) Current and new challenges in occupational lung diseases by Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K. Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard. (European Respiratory Review)

Healthy Food Onion Kills Colon Cancer in Vitro

By Kyle J. Norton

Colon cancer is a chronic condition caused by irregular cell growth in the colon tissue.

The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Most cases of colon cancer start with the alternation of cells DNA on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor.

Colon cancer is relatively very common, slowly growing and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.

In 2019, 101,420 people in the US will be diagnosed with colon cancer.

The exact causes of colon cancer are unknown. However, out of many risk factors associated with the onset of the disease, inherited syndromes may have a strong implication involved in cancer developing, including

* Familial adenomatous polyposis (FAP):
Familial adenomatous polyposis is an inherited condition in which numbers of benign polyp form mainly in the lining of the large intestine, but they can become malignant due to the mutations in the APC gene inherited from the parents.

* Hereditary non-polyposis colon cancer (HNPCC)
HNPCC, also known as Lynch syndrome. HNPCC) increases the risk of developing colon cancer due to the mutation of genes in repairing DNA damage.

*Turcot syndrome
Turcot syndrome is also a rare inherited condition in which cells become abnormal and form multiple adenomatous colon polyps and eventually turn malignant.

* Peutz-Jeghers syndrome
Peutz-Jeghers syndrome is an autosomal dominant genetic disease with the condition of the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa due to mutations in the gene STK1.

* MUTYH-associated polyposis
MUTYH is a human gene encoding a DNA glycosylase. Mutations in the gene MUTYH increases the risk of developing colon polyps which eventually become cancerous if the polyps are not removed.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a natural ingredient for the treatment of colon cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in HT-29 colon cancer cells.

According to the tested assays, at the ranges from 20-60 micromol/l, Fisetin induced colon cancer cell apoptosis by inhibiting the expression of proteins associated with the antiapoptosis(Bcl-xL and Bcl-2) and promoting the expression of proteins (Bak and Bim) involved in pro-apoptosis.

More precisely, fisetin caused an increase in the protein levels associated with the apoptosis and increased of proteins involved in the suppression of fisetin-induced apoptosis.

The inhibition of cancer cell death was also observed by the effect of Fisetin on the enhanced permeability of the mitochondrial membrane and induced the release of cytochrome c.

Moreover, a gene that suppressed the cancer cell initiation, progression and proliferation such as p53 was also exhibited by Fisetin accompanied by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.

Based on the findings, researchers said, "fisetin induces apoptosis in HCT-116 cells via the activation of the death receptor- and mitochondrial-dependent pathway and subsequent activation of the caspase cascade".

Taken altogether, onion used alone or combined with other remedies may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin by Lim DY1, Park JH. (PubMed)

Phytochemical Carotenoids Protect the Eyes Against Age Related Eye Disease

By Kyle J. Norton

Age-related eye disease is a class of medical condition associated with vision impairment due to aging.

Most common types of age-related eye disease are
* Age-related macular degeneration (AMD) is a medical condition which causes irreversible blurring of the central vision in people over age 60.

Most common symptoms of AMM are slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increased in size.

The risk factor associated AMD is shadowy areas in your central vision or unusually fuzzy or distorted vision, particularly in seeing wavy or blurred, with some dark areas at the center.

* Cataract
A cataract occurred in one or both eyes is a condition characterized by clouding of the lens in the eye that affects vision. Most cases of cataract are found in older adults.

Believe it or not, by age 80, more than half of all Americans either have a cataract or have had cataract surgery.

The risk factor associated cataract are aging, a lifetime of exposure to ultraviolet radiation contained in sunlight, cigarette smoking, a poor diet, and alcohol consumption are some of the prevalent factors associated with cataract developing.

* Diabetic eye disease
Diabetic eye disease is a severe complication of diabetes, a leading cause of blindness as a result of damage to the tiny blood vessels inside the retina.

The risk factor associated with diabetic eye disease is uncontrol diet and poor management of blood glucose.

* Glaucoma
Glaucoma is a medical condition of eye disease as a result of the damage of the nerve of the eye’s optic over time. If left untreated, it can lead to permanent vision impairment and blindness.

The risk factor associated AMD are abnormal intraocular pressure (IOP), history of coronary artery bypass or vascular surgery, moderate-to-high myopia, medical conditions such as diabetes, heart diseases, high blood pressure, and hypothyroidism and long-term use of certain medication such as a corticosteroid.

Conventionally, there is no cure of the diseases, treatment of age-related eye disease is focusing on the improvement of quality of life, reduce symptoms and slow down the progression.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

With an aim to find a natural ingredient for the prevention and treatment of eye diseases, researchers the antioxidant and anti-inflammatory activities of carotenoids and polyphenols.

The study included the search of medical literature on PubMed and Web of Science databases for original studies that investigate the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases.

According to the differentiation of the selected studies, carotenoids (such as lutein, zeaxanthin, and neoxanthin) exerted significant preventive and therapeutic benefits against the aforementioned age-related eye diseases.

The efficacy of carotenoids in the protection of the age-related vision was attributed to the phytochemical in

* Mitigating the production of reactive oxygen species, through its antioxidant activity.

* Inhibiting the tumor necrosis factor-α and vascular endothelial growth factor pathways involved in the stimulation of the formation of blood vessels in age-related ocular diseases.

*Protecting the cells in the eye against the overexpression of pro-inflammatory cytokines

* Suppressing the gene associated with cell apoptosis

Based on the finding, researchers wrote, "This review discusses the role and mechanisms of ...carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation".

Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of age-related eye diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases by Bungau S1, Abdel-Daim MM2,3, Tit DM1, Ghanem E4, Sato S3, Maruyama-Inoue M3, Yamane S3, Kadonosono K. (PubMed)
(2) The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)

Friday, 28 June 2019

Bromelain Blocks the Onset and progression of Invasive Glioma in Vitro

By Kyle J. Norton

A glioma is a type of brain and spinal cord tumor characterized by the alternation of DNA of the glial cells.

Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.

Glioma can be classified into 3 types, including

* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.

* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.

* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.

The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,

Out of many prevalent factors, exposure to ionizing radiation has been found in many patients with glioma.

Dr. Maricruz Rivera, the lead scientist wrote, "Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 12–15 months with treatment consisting of surgical resection followed by ionizing radiation (IR) and chemotherapy".

And, "While IR provides the benefit of improved survival, it paradoxically promotes a selection of more malignant cellular phenotypes of GBM".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of invasive glioma cells, researchers investigated bromelain, an aqueous extract from pineapple stem against anti-invasive gliomas.

According to the tested assays, bromelain significantly and reversibly reduced glioma cell adhesion, migration, and invasion without affecting cell viability.

In other words, bromelain inhibited cancer cell proliferation and spreading without inducing cell apoptosis.

Levels of alpha 3 beta 1 integrin-associated with gliomas cells spreading and CD44 protein associated with cancer cell progression were also inhibited by the administration of bromelain without affecting the gene expression.

In other words, the metabolic pathways for de novo nucleotide synthesis in cancer growth were greatly attenuated by bromelain.

Moreover, according to the transactivating signaling assay, bromelain inhibited the invasive glioma cell was also attributed to the suppression of CRE-mediated signaling processes in stimulating the tumor expansion.

Taken altogether, bromelain may be considered supplements for the prevention and treatment of invasive glioma cells. , pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Bromelain reversibly inhibits invasive properties of glioma cells by Tysnes BB1, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. (PubMed)
(2) Ionizing Radiation in Glioblastoma Initiating Cells by Maricruz Rivera,1,2 Kumar Sukhdeo,1,3 and Jennifer Yu. (PMC)

Cucumber's Cucurbitacin B (CuB), Promotes Antimicrobial Activity

By Kyle J. Norton

Antimicrobial activity is the process that either kills or inhibits the microorganisms that induce damage to the body tissues.

In other words, antimicrobial activity is the process of killing or inhibiting the disease-causing microbes, including the use of antibiotics for treatment of infectious disease caused by bacterias and fungi.

Most common diseases associated with microbial infection include

* Diseases caused by bacteria are totally dependent on the types of bacterias, such as pneumonia, caused by Streptococcus and Pseudomonas, and foodborne illnesses caused by bacteria such as Shigella, Campylobacter, and Salmonella.

* Diseases caused by the virus include smallpox. the common cold and different types of flu. measles, mumps, rubella, chicken pox, and shingles. hepatitis. herpes and cold sores. polio. rabies, Ebola and Hanta fever.

* Diseases caused by parasites are malaria, trichomoniasis, giardiasis, cryptosporidiosis, and toxoplasmosis.

* Diseases caused by fungi aspergillosis usually occurs in patients with lung diseases or weakened immune systems and Candidiasis is caused by the yeast Candida.

Depending on the types of microbial infection, most common symptoms are fever, diarrhea, fatigue, muscle aches, and coughing

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound with antibiotic property, researchers investigated extracts purified by dialysis and ion exchange chromatography strategy antibacterial activity against four standard pathogenic bacterial strains.

According to the tested assays, the elute fractions 1 and 3 (370 mg/mL) showed the greatest anti-bacterial activity compared to elute fractions 2 and 4 (340 mg/mL).

Furthermore, among the bacteria utilized, E. coli was clearly the most sensitive compared to other strains.

Additionally, according to the bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems induced (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3), compound 1 showed a relatively low polarity aglycone but exhibited stronger antimicrobial activity than its corresponding glycoside 2.

Dr. Tang J, the lead scientist wrote, "The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems".

Taken altogether, cucumber processed a high amount of phytochemicals may be used for the treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Purification and MIC analysis of antimicrobial proteins from Cucumis sativus L. seeds by Al Akeel R1, Mateen A1, Alharbi KK1, Alyousef AA1, Al-Mandeel HM2, Syed R. (PubMed)
(2) Antimicrobial activity of sphingolipids isolated from the stems of cucumber (Cucumis sativus L.) by Tang J1, Meng X, Liu H, Zhao J, Zhou L, Qiu M, Zhang X, Yu Z, Yang F. (PubMed)

Phytochemical Betacyanins Protects the Lipid, Protein and Cell DNA Damage Caused by Oxidative Stress

By Kyle J. Norton

According to the free radical theory, a free radical with a single unpaired electron in an outermost shell and highly reactive to react with other cells, which in turn, causes oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA and RNA,..,

The theory also suggested that human aging is a result of widespread skin damage caused by a set of chain reaction auto-catalytically of overexpression of free radical after attacking the lipid bilayers of the cell walls.

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radical that cannot be stopped.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidant produced by the host that exists in a long period of time.

Free radicals are unstable atoms with an unpaired electron in the outermost ring. Therefore, in order for them to become stable, free radicals must steal or donate an electron from or to other atoms.

Long-term expression oxidative stress has been found to cause damage to the protein, lipid, and cell DNA, leading to an increased risk of chronic disease, including heart disease, diabetes, and cancers.

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

Normally, antioxidant enzymes by the body are more than enough to counter the expression of free radicals occurred in our body every day. However, in people with a weakened immune system intake of dietary antioxidants such as supplement or fruits may improve levels of antioxidant in the body.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant effects of beetroot (Beta vulgaris L.) juice (BRJ), a good source of betalain (betacyanins and betaxanthin) pigments.

The study included rats with isoproterenol (ISP85 mg/kg injected at 24 h intervals)-induced myocardial ischemia followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.

According to the tested results

* Pretreatment with BRJ (150 and 300 mg/kg) restored the cardiac endogenous antioxidants and reduced levels of oxidative/nitrosative stress, in rats treated by ISP.

* Overexpression of cardiac inflammatory cytokines such as TNF-α, IL-6, and IL-10 caused by ISP was inhibited by the pretreatment of BRJ compared to the untreated group.

* Futhermore, hyperlipidemia level induced ISP was significantly reduced by the BRJ pretreatment.

* Moreover, BRJ also protected against the extent of histological damage, myonecrosis, and edema, and maintained the architecture of cardiomyocytes by exhibiting the effects of anti-apoptotic protein such as Bcl-2 and inhibiting the effects of apoptotic proteins.

These results strongly suggested that betacyanins and betaxanthin found in BRJ mitigate cardiac dysfunction and structural damages by decreasing oxidative stress, inflammation, and apoptosis in cardiac tissues.

Based on the findings, researchers said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".

Taken altogether, betacyanins found abundantly in beetroot may be considered a remedy for the prevention and treatment of disease associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)

Turmeric, the Natural Gastro-Protective Functional Food

By Kyle J. Norton

Scientists may have found kitchen spice which processes a gastroprotective bioactive ingredient for the prevention of gastrointestinal disorders with no side effects, according to studies.

Gastroprotection is a process which contributes to the protection of the GI tract against damage and injury.

Gastrointestinal disorders are a class of conditions associated with the gastrointestinal tract, including injury and damage.

Functional gastrointestinal (GI) and motility disorders characterized by persistent and recurring GI symptoms are the most common GI disorders in the general population in the Western world

In order words, any damage, injury that cause improper functioning of the esophagus, stomach, small intestine, large intestine and rectum, and the accessory organs of digestion, the liver, gallbladder, and pancreas are considered gastrointestinal disorders.

According to the statistics provided by the National Institute of Diabetes, Digestive, and Kidney Diseases, GI disorders affect between 60 -70 million people in the US in 2010. Over 48.3 million (2010) who use ambulatory care are associated with gastrointestinal (GI) disorders.

Out of many diseases associated with GI disorders, chronic constipation is one of the most prevalent conditions that affect 63 million Americans in 2000.

Most common symptoms of GI disorders included upset stomach, indigestion, nausea, vomiting, and diarrhea or constipation accompanied by specific symptoms depending on the infected area.

The causes of GI disorders are multiple. Bacterial and viral infection, inflammation, lactase deficiency, conditions associated with GI damage such as ruptured or perforated organs, GI muscle dysfunction, and long-term use of anti-inflammatory drugs are some prevalent risk found in patients with GI disorders.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

On finding a natural compound with gastroprotective activity, researchers investigated the gastroprotective activity of C. purpurascens rhizome hexane extract (CPRHE) against ethanol-induced gastric ulcers in an animal model.

The study included 36 rats (18 males and 18 females) induced acute toxicity treated with a low dose of CPRHE (1 g/kg), high dose of CPRHE (2 g/kg) and vehicle (5% Tween 20).

CPRHE acute toxicity test on rats did not reveal any signs of mortality and toxicity up to 2 g/kg. However, at doses of 200 mg/kg and 400 mg/kg, CPRHE exerted similar protective effects as of those of omeprazole (positive control) at a dose of 20 mg/kg to rats in remarkable attenuation of gastric lesions induced by ethanol.

Furthermore, pre-treatment of rats with CPRHE significantly protected the gastro integrity by replenishing the depletion of mucus content caused by ethanol administration and decreasing the acidity of gastric walls.

Injection of CPRHE also improved the antioxidant profiles and reduced malondialdehyde level in gastric mucosa compared to the lesion control group.

According to the Immunohistochemical staining assays, CPRHE inhibited the production of proteins associated with the production of inflammatory cytokines during stress.

Based on the findings, researchers wrote, " these findings confirmed the gastroprotective effect of Curcuma purpurascens rhizome against gastric damage".

In order to reveal more information of turmeric effect on the digestive system, researchers investigated the herbal gastroprotective effect in the rat's induced gastric ulcer by ethanol.

The study included normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control administered with 20 mg/kg omeprazole (reference drug) and 2 groups received 250 mg/kg and 500 mg/kg of the leaf extract, respectively.

Oral administration of curcumin extract showed significant gastric protection effect observed by the decrease of ulcer areas remarkably.

Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury.

Furthermore, the leaf extract also enhanced the production of antioxidant enzymes accompanied by t.he proinflammatory cytokines induced by overexpression of free radicals.

The marker of oxidative stress malondialdehyde was also reduced significantly by the extract.

Dr. the lead scientist wrote in the final report, "Results showed leaf extract of Curcuma xanthorrhiza can enhance the gastric protection and sustained the integrity of gastric mucosa structure. Acute toxicity test did not show any sign of toxicity (2 g/kg and 5 g/kg)".

Taken altogether, turmeric may be considered a gastroprotective supplement for the prevention and treatment of diseases associated with the digestive system, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of acute toxicity and gastroprotective activity of curcumapurpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats by Rouhollahi E1, Moghadamtousi SZ, Hamdi OA, Fadaeinasab M, Hajrezaie M, Awang K, Looi CY, Abdulla MA, Mohamed Z. (PubMed)
(2) Gastroprotective effect of ethanolic extract of Curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in Sprague-Dawley rats by Rahim NA1, Hassandarvish P2, Golbabapour S3, Ismail S4, Tayyab S4, Abdulla MA. (PubMed)

Thursday, 27 June 2019

Alliin, the Best Anti Acute Respiratory Distress Syndrome (ARDS) Phytochemical

By Kyle J. Norton

Acute respiratory distress syndrome (ARDS) is a medical condition caused by the building up fluids in the tiny, elastic air sacs (alveoli) in the lungs.

In other words, the fluid retention reduced the function of the lung from filling with enough oxygen-rich air and exhaling carbon dioxide, that leads to depriving the organs function.

According to the statistics, the incidence of acute lung injury acute respiratory distress syndrome (ARDS) ranges from 1.3 to 22 per 100,000 people. The condition remains a significant source of morbidity and mortality in the critically ill patient population in the US.

Depending on the severity of the condition, some patients may experience symptoms of severe shortness of breath, unusually rapid breathing, low blood pressure, confusion, and extreme tiredness due to reduced oxygen to reach the target organs.

Medical conditions such as lung injury from various causes, septic, pneumonia, pancreatitis and, massive blood transfusions and burns and inhaling certain toxic chemicals are some common causes of acute lung injury.

Over time, acute lung injury has been found to induce complication of pneumothorax, pulmonary fibrosis, blood clot, and lung infection.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the prevention of lung injury, researchers examined the protective effects and molecular mechanism of alliin on acute respiratory distress syndrome (ARDS)in an animal model.

The investigation included BALB/c mice induced lung injury by intranasal instillation of lipopolysaccharides (LPS) followed by the alliin administration intraperitoneal to mice 1 h after the treatment.

According to the tested assays, LPS injection caused the elevated lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio was inhibited by alliin.

The elevated levels of pro-inflammatory cytokines induced by LPS on tested mice also markedly decreased by the antioxidant activity of the phytochemicals.

Most importantly, lung pathological injury caused by LPS was attenuated by treatment of alliin.

Furthermore, alliin also blocked the NF-κB activation that contributes to the pathogenic processes of various inflammatory diseases.

Additional differentiation of the efficacy of alliin on the effect of LPS, researchers found that alliin protects the lung injury against LPS by stimulating the nuclear receptor ( (PPARγ) in the superfamily of ligand-inducible transcription factors that regulate adipogenesis, lipid metabolism, cell proliferation, inflammation, and insulin sensitization.

Based on the findings, researchers said, " these results suggested that alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response".

And, "Alliin might be used as an anti-inflammatory agent in the treatment of acute lung injury (ALI)".

Taken altogether, alliin may be considered supplements for the protection of the lung against injury, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.