By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
II. Causes of dementia
I. Genetic Mutation causes of dementia
Genetic mutation is a condition of changes of DNA structure
and alteration in the inherited nucleic acid sequence of the
genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their
children.
1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26
Genetic mutation of chromosome
2q35-q36 Lewy bodies (DLB) are multiplex due to its complex mechanism than generally monogenic disorders. Identifying the first
familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)
2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high
risk of cognitive decline due to the recurrent R155H mutation, according to University of Genova(171).
3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid
precursor protein (APP ) gene, presenillin gene (PSEN-1), and
presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).
4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation
was found to associated to significantly decreased cerebral blood flow
(CBF) affecting brain capillaries(173) and contributing to the early on
set of dementia.
5. Mutations in the NOTCH3
Mutations
in the NOTCH3 gene are responsible for hereditary stroke disorder,
contributed to an adult onset of hereditary ischemic
stroke, vascular dementia and psychiatric disorders(174).
6. Etc.
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References
(170) http://www.ncbi.nlm.nih.gov/pubmed/20164589
(171) http://www.ncbi.nlm.nih.gov/pubmed/18341608
(172) http://www.dementiaguide.com/aboutdementia/typesofdementia/geneticmutations/
(173) http://www.ncbi.nlm.nih.gov/pubmed/22422914
(174) http://www.ncbi.nlm.nih.gov/pubmed/22053260
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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