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Wednesday, 17 December 2014

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Free radical causes of dementia (Lou Gehrig's disease(Amyotrophic lateral sclerosis))

By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

               Diseases of Central Nervous system

                                 Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
B. Free radical causes of dementia
B.4. Lou Gehrig's disease(Amyotrophic lateral sclerosis)
1. Free radicals and Lou Gehrig's disease
Researchers found that glutamate in the synapses enhances the production of free radicals(77) only in motor nerve cells but spares other nerve cells(74) such as cells control senses and other body functions, causing more production of free radicals in disrupting of astrocytes in regulated glutamate levels(76).

2. Antioxidants and Lou Gehrig's disease
a. Vitamin B12 (methylcobalamin)

High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).

b. Vitamin E

Vitamin E protects against cell membranes from lipid peroxidation damage(80) in reduced the risk of breakdown of the cell membrane cause of ALS(81).

c. Superoxide dismutase enzyme 

Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).

d. Cerebral cortex

 Oxidative stress and DNA alternation triggered neurons damage(84) were found in elevating levels in  mice with ALS(85).

e. Amino acids 

 Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).

f. Etc.

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References

(74)  http://www.ncbi.nlm.nih.gov/pubmed/25384799
(75) http://www.ncbi.nlm.nih.gov/pubmed/24655927
(76) http://www.ncbi.nlm.nih.gov/pubmed/25131692 
(77) http://www.ncbi.nlm.nih.gov/pubmed/7561868  
(78) http://www.ncbi.nlm.nih.gov/pubmed/21237187 
(79) http://www.ncbi.nlm.nih.gov/pubmed/17969354
(80) http://www.ncbi.nlm.nih.gov/pubmed/24068194 
(81) http://www.ncbi.nlm.nih.gov/pubmed/23286756
(82) http://www.ncbi.nlm.nih.gov/pubmed/25316790 
(83) http://www.ncbi.nlm.nih.gov/pubmed/24024135 

(84) http://www.ncbi.nlm.nih.gov/pubmed/12132589
(85) http://www.ncbi.nlm.nih.gov/pubmed/?term=Oxidative+stress+and+DNA+alternation++in+Als
(86) http://www.ncbi.nlm.nih.gov/pubmed/24129262
(87) http://www.ncbi.nlm.nih.gov/pubmed/8255440