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Wednesday, 2 July 2014

Phytochemical Polysulfides and Immunity

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in oxidized product, including beer, wine, whiskey, garlic oil, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
A range of sulfur-containing natural products showed to inhibit their antioxidant, antibacterial, antimicrobial, antifungal and anticancer properties, through specific chemical properties which converge in chemotypes, including polysulfides(1).
Garlic extracts and individual components, i.e., allicin, ajoen, polysulfides, essential oil, showed  a significant antifungal activity, according to 1Katedra farmaceutick√© botaniky a ekologie Farmaceutick√© fakulty Univerzity Karlovy(2). Polysulfides, through its biological activity, showed effectively against candidosis in mice, according to the 1Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Japan(3).

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References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(1) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovov√° M1, Sova P.(PubMed)
(2) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed