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Saturday, 19 July 2014

Phytochemical Indole-3-carbinol and Lung cancer

By Kyle J. Norton

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin,  found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
In mice study, Indole-3-carbinol showed to inhibit ling cancer via modulation of the receptor tyrosine kinase/PI3K/Akt signaling pathway(1), in dose dependent manner(2), In support of the above, the study by Medical College of Soochow University, indicated that I3C reduces radiosensitivity of lung cancer cells by mediating EGFR expression, indicating that EGFR may be an important target for I3C-mediated radioresistance in lung cancer. In deed, the individual of indole-3-carbinol or silibinin, showed to inhibit 43 and 36% reductions, respectively, in the multiplicity of tumors on the surface of the lung and 83 and 50% reductions, respectively, and mixtures of I3C and silibinin are more potent than the individual compounds for the chemoprevention of lung cancer in A/J mice, according to University of Minnesota(4).


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References
(1) Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis by Qian X1, Melkamu T, Upadhyaya P, Kassie F.(PubMed)
(2) Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol by Kassie F1, Matise I, Negia M, Upadhyaya P, Hecht SS.(PubMed)
(3) [EGFR-dependent impact of indol-3-carbinol on radiosensitivity of lung cancer cells].

[Article in Chinese] by Xiao X1, Meng Q, Xu J, Jiao Y, Rosen EM, Fan S.(PubMed)
(4) Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice by Dagne A1, Melkamu T, Schutten MM, Qian X, Upadhyaya P, Luo X, Kassie F.(PubMed)