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Tuesday, 19 November 2013
Precocious Puberty - Peripheral Causes
I. Precocious Puberty refers to the sexual and physical characteristics mature occurring at an unusually early age such as before age 7 or 8 in girls and age 9 for boys.
Understand the process of puberty
The process of puberty begins with production of gonadotropin-releasing hormone (Gn-RH) from the brain, which in turn stimulates the pituitary gland to produce the luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These two hormones again stimulates the ovaries in girls and testicles in boys to produce estrogen and testosterone responsible for the growth and development of girl and male sexual characteristics respectfully.
II. B. Peripheral causes
Peripheral cause of the release of estrogen or testosterone into the body because of problems with the ovaries, testicles, adrenal glands or pituitary gland.
1. Germ cell tumors
In the study of "Intracranial choriocarcinoma causing precocious puberty and cured with combined modality therapy by Massie RJ, Shaw PJ, Burgess M., researchers reported a case of precocious puberty in an 8 year old boy due to a malignant intracranial germ cell tumour.
2. Adrenal tumors
Adrenal tumors can suppress the production of melatonin hormone, causing precocious puberty according to the study of Effect of neonatal melatonin administration on sexual development in the rat by Esquifino AI, Villanúa MA, Agrasal C..
3. Gonadal tumors
Gonadal tumors can effect the normal production of sexual hormone in girls and boys.
4. Ovarian cysts and tumors
Ovarian cysts and tumors can affects the production of sexual hormones in girl, which lead to precocious puberty in girls.
5. Gene mutation
Gene mutation can effect the gem cells in production of testosterone in boys, according to the the study of "Intracranial choriocarcinoma causing precocious puberty and cured with combined modality therapy by Massie RJ, Shaw PJ, Burgess M.
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