Polymalagia Arthritis - The diet

Polymalagia Arthritis Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.

The diet
1. Organic Soy 
In the study to examine the role of TK activity on the expression of the inducible nitric oxide (NO) synthase (iNOS), found that TK inhibition by genistein had no effect on the expression or nuclear translocation of the transcription factors interferon regulatory factor-1 and nuclear factor-KB, respectively, both of which have been implicated in transcriptional regulation of the human iNOS gene. Nuclear run-on analysis demonstrated that the effect of genistein on iNOS messenger RNA expression was not at the level of transcription, suggesting that posttranscriptional regulation of iNOS messenger RNA might be TK dependent. Isoflavones, such as genistein, are useful tools to dissect regulatory pathways in vitro and in vivo and may have potential use as novel antiinflammatory therapeutic agents(31).
 2.  Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
a.  Immune system
a. 1. In the investigation of the immunomodulatory effects of decaffeinated green tea extract in rain bow of the study of “Immunomodulatory effects of decaffeinated greentea (Camellia sinensis) on the immune system of rainbow trout (Oncorhynchus mykiss)” by Sheikhzadeh N, Nofouzi K, Delazar A, Oushani AK.(32), researchers found that showed that decaffeinated green tea in lower doses of administration could be optimum to enhance the immunity of rainbow trout(32).
a.2. In the investigation of Green tea and Arthritis of the study of “Greentea polyphenol epigallocatechin 3-gallate in arthritis” by Ahmed S., researcher indicated that although these findings provide scientific evidence of the anti-rheumatic activity of EGCG, further preclinical studies are warranted before phase clinical trials could be initiated with confidence for patients with joint diseases(33).
3. Olive oil
Olive is belongs to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is also called the olive and the source of olive oil.
a. Olive oil phenolics
In the evaluation of the olive oil phenolics of the Mediterranean diet and its lower incidence of atherosclerosis, cardiovascular disease, and certain types of cancer, found that olive oil phenolics have positive effects on certain physiological parameters, such as plasma lipoproteins, oxidative damage, inflammatory markers, platelet and cellular function, and antimicrobial activity, according to “Chemistry and health of olive oil phenolics” by Cicerale S, Conlan XA, Sinclair AJ, Keast RS.(34)
b. Antioxidants and weight loss
In the analyzing the influence of a Mediterranean dietary pattern on plasma total antioxidant capacity (TAC) found that Mediterranean diet, especially rich in virgin olive oil, is associated with higher levels of plasma antioxidant capacity. Plasma TAC is related to a reduction in body weight after 3 years of intervention in a high cardiovascular risk population with a Mediterranean-style diet rich in virgin olive oil, according to “A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain” by Razquin C, Martinez JA, Martinez-Gonzalez MA, Mitjavila MT, Estruch R, Marti A.(35)
4. Salmon 
a. Antioxidants
In the research of the antioxidant effect of vitamin E after ingestion of salmon found that that megadoses of vitamin E, far from having pro-oxidative activity, actually increase the anti-oxidative capacity of the liver, especially after ingestion of salmon oil, according to “Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil” by Flader D, Brandsch C, Hirche F, Eder K.(36)
b. Selenium
Salmon contains trace minerals selenium which is essential for the healthy function of the thyroid and immune system as it increases the antioxidant defense system by fighting against the forming of free radicals and reduce the risk of irregular cells growth causes of tumor and cancer, according to the study of “Selenium in the immune system” by Arthur JR, McKenzie RC, Beckett GJ.,(37)
c.  Omega 3 fatty acids
Omega 3 fatty acids is necessary to maintain the ratio of good and bad cholesterol, thus reducing the risk of cholesterol inflammation according to the study of “In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation” by Wang S, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH., posted in PubMed (IV) and forming of free radical in the heart cells, leading to heart diseases. It also reduces the risk of plaque forming in the arterial wall, thus also decreasing the risk of stoke, according to the study of “N-3 vs. saturated fattyacids: effects on the arterial wall” by Sudheendran S, Chang CC, Deckelbaum RJ., posted in PubMed (38).
5.  Circuit fruits
Circuit fruit contain high amount of Quercetin which can reduce the risk of Rheumatoid Arthritis as a result of anti inflammatory and antioxidant effects
a. Anti-Inflammatory
According to the study of `Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves of Brasenia schreberi.`by Legault J, Perron T, Mshvildadze V, Girard-Lalancette K, Perron S, Laprise C, Sirois P, Pichette A. (Source from Laboratory for Analysis and Separation of Plant Species (LASEVE), Université du Québec à Chicoutimi , Chicoutimi, Québec, Canada.), posted in PubMed, researchers found that some flavonoids have been reported to possess beneficial effects in cardiovascular and chronic inflammatory diseases associated with overproduction of nitric oxide. Quercetin-7-O-β-D-glucopyranoside possesses anti-inflammatory activity, inhibiting expression of inducible nitric oxide synthase and release of nitric oxide by lipopolysaccharide-stimulated RAW 264.7 macrophages in a dose-dependent manner. Quercetin-7-O-β-D-glucopyranoside also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor.
b. Free radical scavenger
In a study of `Dietary chromones as antioxidant agents-the structural variable.`by Dias MM, Machado NF, Marques MP. (Source from Research Unit “Molecular Physical Chemistry”, University of Coimbra, Portugal.), posted in PubMed, researchers found that from the eighteen tested compounds, three-fisetin, luteolin and quercetin-are shown to act as effective antiradicals. Consistent structure-activity relationships (SARs) were established regarding the antioxidant role of this type of chromone-based system.
6.  Turmeric
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia.
a. Anti inflammatory effects
In a systematic review of the literature was to summarize the literature on the safety and anti-inflammatory activity of curcumin, found that curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation, according to “Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)” by Chainani-Wu N (39)
b. Antioxidants
In the research of a literature search (PubMed) of almost 1500 papers dealing with curcumin, most from recent years, with ll available abstracts were read and pproximately 300 full papers were reviewed, found that curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS). Significant preventive and/or curative effects have been observed in experimental animal models of a number of diseases, including arteriosclerosis, cancer, diabetes, respiratory, hepatic, pancreatic, intestinal and gastric diseases, neurodegenerative and eye diseases, “Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases” by Bengmark S.(40)
7. Etc.

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Sources
(31) http://www.ncbi.nlm.nih.gov/pubmed/19281374
(32) http://www.ncbi.nlm.nih.gov/pubmed/21985858
(33) http://www.ncbi.nlm.nih.gov/pubmed/20447316
(34) http://www.ncbi.nlm.nih.gov/pubmed/19093267
(35) http://www.ncbi.nlm.nih.gov/pubmed/19707219
(36) http://www.ncbi.nlm.nih.gov/pubmed/18577222
(37) http://www.ncbi.nlm.nih.gov/pubmed/12730442
(38) http://www.ncbi.nlm.nih.gov/pubmed/20207121
(39) http://www.ncbi.nlm.nih.gov/pubmed/12676044
(40) http://www.ncbi.nlm.nih.gov/pubmed/16387899