Friday, 22 November 2013

Phytochemicals and High cholesterol

Too much low density lipoprotein LDL known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke. Beside prescription drugs and others, herbs place an important role in helping to lower cholesterol levels. Today because of high cost and side effects of prescription drugs, many people try to seek help from herbalists for cost effectiveness and results.

Types of food to prevent and treat high cholesterol
1. Green tea
 Drinking multiple cups of tea per day is associated with lowering low-density lipoprotein cholesterol (LDL-C). In the study of the impact of a theaflavin-enriched green tea extract on the lipids and lipoproteins of subjects with mild to moderate hypercholesterolemia, indicated that theaflavin-enriched green tea extract is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated(1).

2. Corn and sunflower oils
In a a systematic review that investigates the efficacy of phytosterols/stanols in lowering total cholesterol (TC) and LDL-C concentrations in FH subjects, showed that ihe duration of the studies ranged from 4 weeks to 3 months. Fat spreads enriched with 2.3 +/- 0.5 g phytosterols/stanols per day significantly reduced TC from 7 to 11% with a mean decrease of 0.65 mmol/L [95% CI -0.88, -0.42 mmol/L], p < 0.00001 and LDL-C from 10-15% with a mean decrease of 0.64 mmol/L [95% CI -0.86, -0.43 mmol/L], p < 0.00001 in 6.5 +/- 1.9 weeks compared to control treatment, without any adverse effects. TG and HDL-C concentrations were not affected(2).

3. Coffee
Drinking coffee may be associated with the lowering low density lipoprotein LDL. Dr. Cai L, and the research team at the Peking University Health Science Centershowed that The intake of coffee especially unfiltered coffee is contributed significantly to the increase in TC, LDL-C and TG, and the changes were related to the level of intake. Studies of coffee intake on serum lipids in Asian populations should be performed.European Journal of Clinical Nutrition advance online publication(3).

4. Organic Soy
In the study to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice, showed that Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model(4).

5. Cinnamon bark
In the study of the effect of cinnamon extract on anti-hyperglycemia and anti-hyperlipidemia was evaluated by measuring the blood glucose levels, serum insulin, and adiponectin levels, serum and hepatic lipids, indicated that  cinnamon extract significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism(5).

6. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12824094
(2) http://www.ncbi.nlm.nih.gov/pubmed/16522931
(3) http://www.ncbi.nlm.nih.gov/pubmed/22713771
(4) http://www.ncbi.nlm.nih.gov/pubmed/22787486
(5) http://www.ncbi.nlm.nih.gov/pubmed/20195835

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