Thursday, 21 November 2013

Phytochemicals and Flu (influenza)

Flu (influenza) is defined as a infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses) of that can lead to symptoms of chills, fever, sore throat, muscle pains, severe headache, coughing, etc.


Types of food to prevent and treat Flu (influenza)
1. Green tea
In an observational study to determine the association between green tea consumption and the incidence of influenza infection among schoolchildren, showed that the adjusted OR associated with the consumption of green tea for ≥6 d/wk compared with <3 d/wk was 0.60 [(95% CI = 0.39-0.92); P = 0.02] in cases of influenza confirmed by the antigen test. Meanwhile, the adjusted OR inversely associated with the consumption of 1 cup/d to <3 cups/d (1 cup = 200 mL) and 3-5 cups/d compared with <1 cup/d were 0.62 [(95% CI = 0.41-0.95); P = 0.03] and 0.54 [(95% CI = 0.30-0.94); P = 0.03], respectively. However, there was no significant association with the consumption of >5 cups/d. Our findings thus suggest that the consumption of 1-5 cups/d of green tea may prevent influenza infection in children(1).

2. Turmeric
In the studt to investigate selected polyphenols for their antiviral activity against influenza A and B viruses. Among the polyphenols, isoquercetin inhibited the replication of both influenza A and B viruses at the lowest effective concentration. In a double treatment of isoquercetin and amantadine, synergistic effects were observed on the reduction of viral replication in vitro. The serial passages of virus in the presence of isoquercetin did not lead to the emergence of resistant virus, and the addition of isoquercetin to amantadine or oseltamivir treatment suppressed the emergence of amantadine- or oseltamivir-resistant virus. In a mouse model of influenza virus infection, isoquercetin administered intraperitoneally to mice inoculated with human influenza A virus significantly decreased the virus titers and pathological changes in the lung. Our results suggest that isoquercetin may have the potential to be developed as a therapeutic agent for the treatment of influenza virus infection and for the suppression of resistance in combination therapy with existing drugs.(2).

3.Skin and seed of grape
In the study of assayed the bioactivity of resveratrol as antiproliferative and antiviral drug in cultured fibroblasts. Studies by other Authors showed that this natural compound inhibits the proliferation of different viruses such as herpes simplex, varicella-zoster and influenza A. Resveratrol can effectively inhibit the synthesis of polyomavirus DNA. A possible interpretation is that, due to the damage caused by resveratrol to the plasma membrane, the transfer of the virus from the endoplasmic reticulum to the nucleus, may be hindered thus inhibiting the production of viral DNA(3).

4. Garlic
In the study to demonstrate that aged garlic extract could modify these immune cells in randomized, double-blind, placebo-controlled parallel intervention study recruited 120 healthy subjects (60 per group) to determine the effect of aged garlic extract supplementation (2.56 g/d) on immune cell proliferation and cold and flu symptoms showed that supplementation of the diet with aged garlic extract may enhance immune cell function and that this may be responsible, in part, for reduced severity of colds and flu(4).

5. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21832025
(2) http://www.ncbi.nlm.nih.gov/pubmed/20826184
(3) http://www.ncbi.nlm.nih.gov/pubmed/19570215
(4) http://www.docguide.com/supplementation-aged-garlic-extract-improves-both-nk-and-gamma-delta-t-cell-function-and-reduces-sev

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