Cystic fibrosis is a genetic disease passing through the family affecting the body's epithelial cells. The genetic disease
cause the building up of mucus of that may block the lungs and ducts and
passageway, causing infection and breathing problem.
Diet to prevent and treat Cystic fibrosis
1. Green tea and Red wine
CaCCs perform important functions in cell physiology, including
regulation of epithelial secretion, cardiac and neuronal excitability,
and smooth muscle contraction. CaCC modulators are of potential utility
for treatment of hypertension, diarrhea, and cystic fibrosis. Researchers found that Tannic acid inhibited CaCCs in multiple cell types but did not affect
CFTR Cl(-) channels. Structure-activity analysis indicated the
requirement of gallic or digallic acid substituents on a macromolecular
scaffold (gallotannins), as are present in green tea
and red wine. Other polyphenolic components of teas and wines,
including epicatechin, catechin, and malvidin-3-glucoside, poorly
inhibited CaCCs. Remarkably, a 1000-fold dilution of red wine and
100-fold dilution of green tea inhibited CaCCs by >50%. Tannic acid, red wine, and green tea
inhibited arterial smooth muscle contraction and intestinal Cl(-)
secretion(1).
2. Onion and blueberry
In the study of Cystic fibrosis and non-cystic fibrosis
primary human sinonasal epithelial (HSNE) and murine nasal septal
epithelial (MNSE) cultures for transepithelial ion
transport in Ussing chambers under voltage clamp conditions and CBF was
performed using pharmacologic manipulation, showed that Quercetin significantly increased transepithelial Cl(-) transport and
CBF in MNSE and HSNE cultures. Future studies investigating quercetin as
a means to promote mucociliary transport in individuals with
rhinosinusitis are warranted(2).
3. Skin and seed of grape
In the study of Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1, showed that resveratrol
treatment increased CFTR expression or maturation in immunoblotting
experiments in MDCK1 cells or in CFPAC1 cells. Indirect
immunofluorescence experiments showed a shift of delF508CFTR
localization towards the (peri)-membrane area in CFPAC1 cells and in
human airway epithelial cells. A cAMP-dependent increase in membrane
permeability to halide was detected in resveratrol-treated CFPAC1 cells, and was inhibited by a selective inhibitor of CFTR(3).
4. Flax seed and Fish oil
In the study to evaluates our current knowledge on the association of fatty acid abnormalities in cystic fibrosis
with the disease process, and makes a case for a well-designed clinical
trial to evaluate the clinical efficacy of long chain n-3 fatty acids, showed that the restoration of abnormal fatty acid profiles may be beneficial in cystic fibrosis,
but this approach has not been evaluated in studies with a suitable
design to permit firm conclusions to be drawn. There is a need for a
long-term randomized controlled study to evaluate the therapeutic
benefit of fish oil supplementation in cystic fibrosis(4).
5. Garlic
In the investigation of Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a
pilot randomized controlled trial, showed that at the end of treatment
five patients in each group had abnormal liver function or triglycerides
and five garlic patients (one placebo) reported minor adverse effects.Garlic capsules were well tolerated. Although there was no significant effect of garlic compared to placebo in this pilot study, there was a suggestion of improvement with garlic which should be investigated in a larger trial(5).
6. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20581223
(2) http://www.ncbi.nlm.nih.gov/pubmed/22186243
(3) http://www.ncbi.nlm.nih.gov/pubmed/21366549
(4) http://www.ncbi.nlm.nih.gov/pubmed/15716793
(5) http://www.ncbi.nlm.nih.gov/pubmed/20306535
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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