Thursday, 21 November 2013

Phytochemicals and Fibromyalgia

Fibromyalgia is defined as a condition of chronic widespread pain in the joints, muscles, tendons, and other soft tissues.

Types of food to prevent and treat Fibromyalgia
1. Lean beef and Chicken
In the study to investigate the effect of CoQ(10) on symptoms of five patients with FM, suggested that Patients with CoQ(10) deficiency showed a statistically significant reduction on symptoms after CoQ(10) treatment during 9 months (300 mg/day). Determination of deficiency and consequent supplementation in FM may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm this observation(1)

2. Oat and Rice
In the evaluation of the significance of using different doses of melatonin, alone or in combination with fluoxetine for the management of FMS. A double-blind, placebo-controlled clinical study was performed on 101 patients (95 women and 6 men) who fulfilled the criteria of the American College of Rheumatology (ACR) of FMS, showed that each patient was clinically evaluated through direct interview with the patients using the Fibromyalgia Impact Questionnaire (FIQ) at zero time and after 8 wk. Using melatonin (3 mg or 5 mg/day) in combination with 20 mg/day fluoxetine resulted in significant reduction in both total and different components of FIQ score compared to the pretreatment values. In conclusion, administration of melatonin, alone or in a combination with fluoxetine, was effective in the treatment of patients with FMS(2).

3. Orange juice and Raisin Bran
In the study to evaluate to investigate effects of vitamins C and E (VCE) supplementation with exercise (EX) on antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM), found that Plasma concentrations of vitamins A and E and reduced glutathione were lower in the patients than those in controls and their concentrations were increased by VCE and EX. Glutathione peroxidase activity in erythrocytes was increased by VCE supplementation, with or without EX. Concentrations of β-carotene in the groups did not change with treatment. Despite the measured effects on anti-oxidative mechanisms, FM symptoms were not improved by the treatments. In conclusion, VCE with EX may protect against FM-induced oxidative stress by up-regulation of an antioxidant redox system in the plasma and erythrocytes of patients with FM. Such protective effects of VCE in the patients seemed to be greater in combination with EX than EX alone(3).

4.  Soy
Some researchers suggested that Shakes that contain soy and shakes that contain casein, when combined with a multidisciplinary fibromyalgia treatment program, provide a decrease in fibromyalgia symptoms. Separation between the effects of soy and casein (control) shakes did not favor the intervention. Therefore, large-sample studies using soy for patients with fibromyalgia are probably not indicated(4).

5.  Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21496502
(2) http://www.ncbi.nlm.nih.gov/pubmed/21158908
(3) http://www.ncbi.nlm.nih.gov/pubmed/20666654
(4) http://www.ncbi.nlm.nih.gov/pubmed/18990724

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