Fibroids also known as uterine fibroids, is defined as a condition of irregular cell growth of non cancerous tumor from the muscle layers of the uterus
Types of food to prevent and treat fibroids
1. Green tea
In the study to investigate the effect of epigallocatechin gallate (EGCG) on rat leiomyoma
(ELT3) cells in vitro and in a nude mice model, found that Inhibitory
effect of EGCG (200 micromol/L) on ELT3 cells was observed
after 24 hours of treatment (P < .05). At > or = 50 micromol/L,
EGCG significantly decreased PCNA and Cdk4 protein levels (P < .05).
In vivo, EGCG treatment dramatically reduced the volume and weight of tumors
at 4 and 8 weeks after the treatment (P < .05). The PCNA and Cdk4
protein levels were significantly reduced in the EGCG-treated group (P
< .05)(1). Others suggested that the tumors in
the EGCG fed birds were smaller than those found in the control birds (P
= .001). Serum and liver malondialdehyde and TNF-alpha concentrations
decreased (P = .001) with EGCG supplementation. The results indicate
that dietary supplementation with EGCG reduces the incidence and size of
spontaneously occurring leiomyoma
of the oviduct in Japanese quail. Clinical trials should be conducted
to investigate the efficacy of EGCG supplementation in the prevention
and treatment of uterine leiomyoma in humans(2).
2. Tomato and carrot
In the study to evaluate the carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL), showed that total lycopene intake was not associated with diagnosed UL risk. Intake
of beta-carotene was associated with slightly increased risks of
diagnosed UL; this association was restricted to current smokers (for
highest vs lowest quintile, relative risk = 1.36, 95% confidence
interval 1.05 to 1.76; P(trend) = .003)(3).
3. Turmeric
Uterine leiomyomas are the most common gynaecological benign tumour and
greatly affect reproductive health and wellbeing. Curcumin,
a well-known component of turmeric, has been reported to prevent
various diseases such as cancer, diabetes and obesity. Researchers at
Tohoku University Graduate School of Medicine, suggested that curcumin significantly inhibited ELT-3 cell proliferation. PPARγ was expressed in ELT-3 cells and curcumin acted as a PPARγ ligand. This inhibitory effect of curcumin was attenuated by the treatment of cells with PPARγ antagonist(4).
4. Soy
Genistein is a soy-derived phytoestrogen. In the study to investigated the
siginificant inhibitory effect of genistein on estradiol (E(2))-induced leiomyoma cells proliferation, indicated that PPARgamma was expressed in ELT-3 cells and genistein acted as PPARgamma
ligand. This inhibitory effect of genistein was attenuated by the
treatment of cells with PPARgamma antagonist bisphenol A diglycidyl
ether (BADGE) or GW9662 and suggested that the repressive effect of genistein on E(2)-induced ELT-3 cell
proliferation is through the activation of PPARgamma. Genistein may be
useful as an alternative therapy for leiomyoma(5).
5. Flaxseed
In the study to evaluate the relation between uterine fibroid risk and phytoestrogen exposure, showed that
a modest inverse association between lignan excretion and uterine
fibroid risk. Whether this relation represents an effect of lignans per
se or of other constituents of lignan-containing foods on the
development of uterine fibroids remains to be determined. No association was found between isoflavone excretion and uterine fibroids; however, the intake of soy foods, the primary source of isoflavones, was low in this population(6).
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20074693
(2) http://www.ncbi.nlm.nih.gov/pubmed/19083394
(3) http://www.ncbi.nlm.nih.gov/pubmed/17981250
(4) http://www.ncbi.nlm.nih.gov/pubmed/20672906
(5) http://www.ncbi.nlm.nih.gov/pubmed/19903033
(6) http://www.ncbi.nlm.nih.gov/pubmed/16960173
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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