Monday, 18 November 2013

Phytochemicals and Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta)

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results in death.
Food intake can help to prevent and treat cancers. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.
I. Choriocarinma
Cancer of Choriocarinma is a malignant and aggressive cancer, started from the abnormal and uncontrollable cells growth in the trophoblatistic tissue, that is part of embryo and normally become the placenta as a result of something going wrong during pregnancy due to random chance.
Placenta is the organ by which the fetus received nutrients and oxygen from the mother.

II. Molar pregnancy or Hydatidiffrom mole
Molar pregnancy or Hydatidiffrom mole is also started from the trophoblastic tissue, normally is non cancerous but sometimes, it may invade the uterine wall (invasive mole) as a result of a sperm fusing with an with nucleus or something going wrong during pregnancy causing forming of a mass resembling the bunch of grape.
The two types of molar pregnancy are complete molar and partial molar pregnancy.
a. Complete mole pregnancy happens when a single sperm combining with an egg which is deficient with lost its DNA. The sperm that would otherwise fertilize the egg are then left to reduplicate themselves to form a complete 46 chromosome set.
Generally no fetus results from a complete molar pregnancy. Complete hydatidiform moles have a higher risk of developing into choriocarcinoma and happened in 1 out of 1200 pregnancy.

b. Partial mole pregnancy
A partial mole pregnancy occurs when two separate sperm fertilize the same egg, resulting of the nucleus containing one maternal set of genes and two paternal sets. With a partial molar pregnancy, there may result an actual fetus and placenta but fetus is most likely to develop into a partial mole.
Types of foods to prevent and treat Choriocarcinoma and Hydatidiform Mole

III. Types of foods to prevent and treat Hydatidiform Mole
1. Carnot
Retinoic acid, a types of vitamin A  found abundantly in carrot has exerted the protective effect against
Hydatidiform Mole.  At clinical trial as many as 67 cases met the requirements for the study. Two cases were lost from observation and three experienced pregnancy. The incidence rate of malignant trophoblastic disease in the control group was 28.6%, and in the therapy group was 6.3%. No difference was found in the changes of SGOT and SGPT levels of the therapy group compared with the control group. The rate of malignant trophoblastic disease (MTD) was reduced in the group receiving vitamin A therapy(1).

2. Chinese cucumber 
Trichosanthin found  abundantly in Chinese cucumber has been found to be protective against hydatidiform mole."During 1972-1986, 44 of 52 patients (84.6%) with hydatidiform mole were treated successfully with trichosanthin. Of these, 38 (73.1%) had complete spontaneous evacuation and 6 (11.5%) incomplete evacuation. The average time for evacuation of hydatidiform mole was 4.5 +/- 1.64 days. The amount of bleeding was less than 100 ml in 33 patients (75%), while that in 2 of the patients with incomplete evacuation was more than 300 ml. Malignant changes occurred in two of the 44 patients (4.5%). The malignant rate was similar to that (4-12.5, P greater than 0.05) of prophylactic chemotherapy" Dr. Lu PX and Dr. Jin YC. at Shanghai Second Medical University said(2)

3. Kiwifruit 
Vitamin C and E found in high amount in Kiwifruit is said to be effective in fighting against hydatidiform mole (CHM). In the study to determine the oxidative status and antioxidative status of plasma of patients with complete hydatidiform mole (CHM) and to compare these values with normal pregnancy, showed that total antioxidant potential (TAOP) of plasma was significantly lower in patients with hydatidiform mole than in healthy pregnant women [mean (SD) values were 511.9 (105.8) and 571.7 (109.4) micromol Trolox equiv./L respectively (p <0.05)]. In contrast, mean (SD) total peroxide level of plasma was significantly higher in the patients [21.8 (6.4) micromol H2O2/L] than in healthy pregnant women [15.6 (6.4) micromol H2O2/L (p <0.001)]. The mean oxidative stress index level was significantly higher in patients with CHM than in healthy pregnant women [4.43 (1.70) versus 2.92 (1.50) respectively (p <0.001)] and concluded that Patients with CHM are exposed to oxidative stress, which may have a role in the pathogenesis of the disease. Supplementation with antioxidative vitamins such as C and E could be considered in treatment(3).

4. Etc.
 
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20843153
(2) http://www.ncbi.nlm.nih.gov/pubmed/2164464 
(3) http://www.ncbi.nlm.nih.gov/pubmed/14691728

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