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The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Hyperprolactinemia is a condition of elevated serum of prolactine which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.
High levels of procltine has been found to associate to elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berry may ease the symptoms and treatment of in mild and serve cases of PMS.
According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.
The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors in activated sex hormone for secretion of porclatin.
2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia through inhibiting levels of proclatin through suppressed the stimulation of the mammary gland in response to stressful situations and during deep sleep phases.
Taking together, Chaste tree berry may be beneficiary in reduced symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia induced premenstrual breast pain and discomfort.
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(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)