Sunday, 23 July 2017

Herbal Therapy: Andrographis, The Male Contraceptive Whole Herb Medicine?

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata, the forgotten herb showed the ability to influence the male reproductive organ as a contraceptive option contradictively, a renowned institutes study suggested.

Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka,  used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......

According to the Bharathidasan University, andrographolide, a major chemical constituent of andrographis paniculata affected the process in which spermatozoa are produced from spermatogonial stem cells in the testis by interring the dividing spermatogenic cell lines.

In a 3-month-old male Wistar albino rats at two dose levels, for 48 days, rats fed with andrographolide exerted contraceptive effects by inducing decreased sperm counts, increased in-motile spermatozoa, and several possessed abnormalities.

Dr. Akbarsha MA, the lead research said, "the study points to a male reproductive toxic effect of this compound(andrographolide) when used as a therapeutic".

Unfortunately, also in male Wistar albino rats study, orally administering extract of Andrographis paniculata of 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating, treated group showed no effect on  testosterone levels and fertility indices and  sperm count and sperm motility when compared with the control.

Furthermore, in the comparison of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus with Valeriana officinalis and Panax ginseng, Kan Jang decode exhibited no significant negative effect of Kan Jang on male semen quality and fertility, but rather a increased number of spermatozoids in the whole ejaculate in compared to others herbal treated group.

The conflict results of above studies may be due to types of research design, small sample size and quality of herbal medicine used....., but regardless to above conclusions, large sample size and mutli centers studies are necessary to resolve these contradiction.

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(1) Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa by Akbarsha MA1, Murugaian P.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A1, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats by Allan JJ1, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)