Food Therapy: Cruciferous Vegetables, the Best Natural Whole Food in Reduced risk of Diabetic Vascular Complications

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Diabetic vascular complications are caused by diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.

Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Its complications may include renal failure and cardiovascular events.

Intake of Cruciferous Vegetables regularly may be beneficiary in reduced risk of diabetic vascular complications.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"

Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end products aggravate the diabetic vascular complications via modulating the RAGE receptors in removal of AGE.

According to the Kurume University School of Medicine, sulphoraphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference of pro inflammatory reaction, reduction of oxidate stress.

In cultured cells and experimental animals, sulforaphane suppressed inflammatory activation of vascular cells, induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.

Therefore, intake of Cruciferous Vegetables may reduce risk of diabetic vascular complication as sulphoraphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling of over 500 genes expression of cellular defense mechanisms.

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Sources
(1) Protective role of sulphoraphane against vascular complications in diabetes by Yamagishi S1, Matsui T1.(PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, Xu HQ3.(PubMed)