Wednesday, 5 July 2017

Herbal Therapy: Cayenne, The Best Whole Herb Medicine for Prevention and Treatment of Liver Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

"Let food be your medicine and let medicine be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries.  In order to achieve these, consumption of whole food medicine must accompany with moderated exercise, change of diet and life style.

Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a major ingredient found in cayenne may be used as supplement for protection against liver cancer.
According to recent study by the Duksung Women's University, oral administration of Capsaicin inhibited HepG2 human hepatoblastoma cells, through its antioxidants activities in induction of apoptosis in oxidase-mediated generation of ROS.  

Other studies insisted that cayenne, exerted protection against liver cancer, is the result of inhibition of cancer cells proliferation, migration and invasion of tumors, and induced tumors to radiotherapy and chemotherapy.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions, used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

Liver cancer is a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

In a 4-wk feeding of B6C3F1 mice at 6 wk of age, oral intake of cayenne group expressed not only body weight but also reduced hypoglycemia and cells involved generation of liver cancer.

Dr. Teel RW, autheor of the research said, " At concentrations of 25, 50, and 100 microM, capsaicin inhibited the biotransformation of (Aflatoxin B1(AFB1) produced by hepatitis viral) by modifying Phase I hepatic enzyme activity ( induced damage and injure of liver) "

Furthermore, in the inhibition of toxical metabolism, capsaicin also possessed antimutagenic and anticarcinogenic properties against many types of cancer.

Taking altogether, cayenne may process the anti liver cancer effect, but large quantity intake should only be prescribed by herbalists.

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(1) Spices for Prevention and Treatment of Cancers by Zheng J1, Zhou Y2, Li Y3, Xu DP4, Li S5, Li HB6,7.(PubMed)
(2) Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells by Lee YS1, Kang YS, Lee JS, Nicolova S, Kim JA.(PubMed)
(3) A 4-week feeding study of ground red chilli (Capsicum annuum) in male B6C3F1 mice by Jang JJ1, Devor DE, Logsdon DL, Ward JM.(PubMed)
(4) Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin by Teel RW1.(PubMed)

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