Saturday, 1 July 2017

Food Therapy: Garlic, The Whole Food Medicine for Reduced Risk and Treatment of Gastric Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical research, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

Many researchers have raised questions of their's effectiveness, depending too much on geographic differences, time of grown and harvest, etc.. I do believe, these questions can only be answered by experience herbalist.

Scientists from varies respectable institutions suggested that out of many herbs, garlic may be one of most powerful whole food medicine in reduced risk of gastric cancer due to the effects of phytochemicals.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfered in cell cycle arrest. Administrated garlic induced the reduction of 23% of live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 ┬ÁM DADS treatment for 48 hours..

Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo , may be partly due to its antioxidant and immunomodulative effects"

In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer, probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through influence of cell cycle division and negation of proinflammatory pathways.

Some researchers suggested to use garlic as chemopreventive therapy, as experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.

Therefore, people who add addition portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.

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(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH.(PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)

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