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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
"Let food be your medicine and let medicine be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries. In order to achieve this efficacy, consumption of whole food medicine must be accompanied with moderated exercise, change of diet and life style.
Various studies insisted that garlic is function well in reduced blood cholesterol accumulation.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
In the total of forty 10-month-old, male Wistar rats received intraperitoneal (IP) injection of CsA (25 mg/kg) for 28 days, group received garlic (tablets, 400 mg/d) demonstrated reduced LDL levels compared with controls.
Also in patient with Nephrotic syndrome (NS), characterized by proteinuria, oxidative stress and endogenous hyperlipidemia, 2% garlic diet treatment diminished significantly total-cholesterol, LDL-cholesterol and triglycerides, but not HDL-cholesterol, through the attenuation of the rise of lipoperoxidation.
Dr. Bragg DA and Dr. Walling A said," The evidence to support use of integrative medicine is limited (to treatment of metabolic symdrome), but the strongest evidence of benefit is for garlic (Allium sativum)".
Furthermore, the Wistar male rats randomly divided into 4 diet groups with garlic supplementation study, also support the effect of garlic in treatment of hyperlipidemia, as group treated with 200 mg raw garlic/kg body weight, demonstrated the protective effects on HDL in rats with high LDL intake.
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(1) The effect of garlic on cyclosporine-A-induced hyperlipidemia in male rats by Taghizadeh Afshari A1, Shirpoor A, Dodangeh Balakhani E.(PubMed)
(2) Garlic ameliorates hyperlipidemia in chronic aminonucleoside nephrosis by Pedraza-Chaverrí J1, Medina-Campos ON, Granados-Silvestre MA, Maldonado PD, Olivares-Corichi IM, Hernández-Pando R.(PubMed)
(3) Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes by Pedraza-Chaverrí J1, Maldonado PD, Medina-Campos ON, Olivares-Corichi IM, Granados-Silvestre MA, Hernández-Pando R, Ibarra-Rubio ME.(PubMed)
(4) Metabolic Syndrome: Hyperlipidemia by Bragg DA1, Walling A1.(PubMed)