Wednesday, 26 July 2017

Food Therapy: Asparagus, the Natural Whole Food for Reduced Risk and treatment of Kidney Cancers

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

"Let foods be your medicine and let medicines be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries. In order to achieve these, consumption of whole food medicine must accompany with moderated exercise, change of diet and life style.

Asparagus may be a potential product used for treatment of renal cell carcinoma caused by recurrent abnormal chromosomes in gene and reciprocal gene expression.
According to the Banaras Hindu University, asparagus racemosus leaf extract inhibits growth UOK 146 renal cell carcinoma through cytotoxic activitie and downgraded the process of genes responsible for proliferation of the UOK146 cell line.

Dr. Verma SP, the lead author said, " Evidence of antiproliferative effect, PRCC-TFE3(recurrent abnormal chromosomes in gene and reciprocal gene expression) fusion transcript inhibition and static anti- or pro-apoptotic regulators(BAX0 level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation"

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia, used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Renal cell carcinoma (Kidney cancer/renal cells) is a type of kidney cancer caused by malignant cells of the limning of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

Shatavarins (containing shatavarin IV) isolated from the roots of Asparagusracemosus  exerted anti cancer properties, in vivo against numbers of cancer cell lines, including A-498 (human kidney carcinoma) cell lines .

Oral administration of shatavarin to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days,, inhibited tumor cell volume and increased non-cancer cell count, through its potent cytotoxicity,  compared to the untreated mice of the EAC control group.

The herbal decode also restore the normal expression of red (RBC) and white blood cell (WBC) counts and hemoglobin (Hb) concentration which are altered in patients with renal cell cancer.

There is no doubt that Asparagus has exhibited significant anticancer activity in both in vitro and in vivo experimental models but further multi and large size studies are necessary to confirm this potency.

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(1) The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay by Medendorp K1, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG.(PubMed)
(2) Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes by Weterman MA1, van Groningen JJ, den Hartog A, Geurts van Kessel A.(PubMed)
(3) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death by Verma SP1, Tripathi VC, Das P.(PubMed)
(4) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus by Mitra SK1, Prakash NS, Sundaram R.(PubMed)