Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : July 2017

Monday, 31 July 2017

Food Therapy: Kidney Beans Uncooked May Induce Gastrointestinal Dysfunction

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Raw or undercooked kidney beans (Phaseolus vulgaris L.) may cause chronic indigestion inducing functional permutation in various gastrointestinal tissues, a study by renowned institutes suggested.

In 20 young male rats randomly divided into two groups of 10 rats, the first group served as the control and gavaged with 300 mg of a rodent pellet flour suspension (RPFS)anf the second experimental group challenged with 300 mg of a Beldia bean flour suspension (BBFS) for 10 days, group fed with white kidney bead suspension demonstrated intestinal alterations characterized by abnormal of shaggy hair. tiny hairlike folds in the plasma membrane that extend from the surface of many absorptive or secretory cells with short and dense or long and slender features.

Dr. Nciri N the lead author also found that group fed with 300 mg of a Beldia bean flour suspension (BBFS) also experience the distorted function of jejunum and disturbed hydroelectrolytic balancing.
Also in the same study groups, oral intake of beldia bean flour suspension (BBFS) group exhibited increased levels of phytohemagglutinins (PHAs), a toxic protein found in extracted from the kidney bean in interaction with a mucous membrane in the small intestine.

The presence of immunogenic intraluminal PHAs was found within 3-4 h after the oral intake of the BBFS.

The interaction of the toxic compound with a mucous membrane in the small intestine, may be potentially resulting in an inflammatory response, inducing digestive dysfunction.

Dr. Torres-Pinedo R. not the researcher in the above study said, "Lectins( found abaundantly in kidney bean) are contained in significant amounts in a great variety of products ingested in the human diet. This, and the demonstration of their harmful effects on intestinal epithelium in rodents, indicate a need for investigation of potential adverse actions of lectins on human intestine".

Truly, there is no doubt that raw and under-cooked kidney bean can contain certain toxic chemical compounds, which interfere with the digestive function, causing chronic digestion and in some cases serve intoxication.

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Sources
(1) Effect of White Kidney Beans (Phaseolus vulgaris L. var. Beldia) on Small Intestine Morphology and Function in Wistar Rats BY Nciri N1,2,3, Cho N3, Bergaoui N1, El Mhamdi F1, Ben Ammar A4, Trabelsi N5, Zekri S1, Guémira F5, Ben Mansour A1, Sassi FH1, Ben Aissa-Fennira F1.(PubMed)
(2) Identification and Characterization of Phytohemagglutinins from White Kidney Beans (Phaseolus vulgaris L., var. Beldia) in the Rat Small Intestine by Nciri N1,2,3, Cho N3, El Mhamdi F1, Ben Mansour A1, Haj Sassi F1, Ben Aissa-Fennira F1.(PubMed)
(4) Lectins and the intestine by Torres-Pinedo R.(PubMed)

Herbal Therapy, Chaste tree berry, The Whole Herb Medicine for Treatment of Hyperprolactinemia Associated to Premenstrual Syndrome

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Hyperprolactinemia is a condition of elevated serum of prolactine which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.

High levels of procltine has been found to associate to elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berry may ease the symptoms and treatment of in mild and serve cases of PMS.

According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.

Dr. YE Q, the lead author in the study said, casticin ameliorated the stimulation of pituitary cells with 17β-Estradiol (E2), a female sex hormone in prolactin secretion..

The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors in activated sex hormone for secretion of porclatin.

In the review of pharmacology and clinical indications of the effectiveness of chaste tree berry in PMS women. the University of Göttingen found that

1. The herbal extract consisted a beneficially influence in most common premenstrual symptoms, indicated by a double-blind placebo-controlled studies.
2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia through inhibiting levels of proclatin through suppressed the stimulation of the mammary gland in response to stressful situations and during deep sleep phases.

Dr. Wuttke W said" The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects" and "dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome".

Taking together, Chaste tree berry may be beneficiary in reduced symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia induced premenstrual breast pain and discomfort.

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Sources
(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)

Sunday, 30 July 2017

Herbal Therapy: Aloe Vera, the Anti Constipation Natural Whole Food Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Recent study suggested that Aloe Vera may process an anti constipation effect, through the expression of improved intestinal motility, increased fecal volume and normalized body weight.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe Vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
Constipation is a condition in difficulty in emptying the bowels, in most case associated with hardened feces.

According to the University of Fort Hare, in a constipation condition induced by oral administration of loperamide (3 mg/kg body weight) in comparison of control rats received normal saline, intake of aqueous leaf extract of Aloe ferox Mill. with 50, 100 and 200 mg/kg body weight/day or 7 days improved laxative property with the best efficacy in 200 mg/kg body weight.

Dr. Wintola OA, the lead researcher said, "The effect of the extract compares favourably well with senokot, a standard laxative drug. These findings have therefore, lent scientific credence to the folkloric use of the herb as a laxative agent.."

Addition to the above, also in loperamide-induced constipated rats, intake of aqueous extract of Aloe ferox Mill. showed no toxicity to the kidney and liver even with of highest doses of 200 mg/kg body weight for 7 days. The study also insisted that extract is very effective in compared favourably with senokot, a recommended drug for the treatment of constipation.

Taking together, even though living with constipation is an irritable and uncomfortable experience but the use of herbal medicine in treatment of constipation should be taken with care. People should start with small doses and increase the amount gradually.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipationin Wistar rats by Wintola OA1, Sunmonu TO, Afolayan AJ.(PubMed)
(2) A qualitative study of quality of life and the experience of complementary and alternative medicine in Korean women with constipation by Lee EJ1, Warden S.(PubMed)
(3) Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats by Wintola OA1, Sunmonu TO, Afolayan AJ.(PubMed)

Food Therapy: Cruciferous Vegetables, the Best Natural Whole Food Medicine for Reduced risk of Inflammation in Adult with Gene GSTT1

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

In a randomized controlled trial in healthy young adults, isothiocyanates found in cruciferous vegetable, exhibited anti inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP)), in increased increases in the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.

Intake of Cruciferous Vegetables has shown to reduced the circulation of proinflammatory cytokins, namely IL-6 through inhibited the expression of abnornal function of gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower the levels of glutathione, the anioxidant with anti inflammatory properties.

Dr. Navarro SL, the lead researchers said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively]" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1".

In support of the above study, isothiocyanates (ITC) from cruciferous vegetable showed to increase levels of serum of Glutathione S-transferases (GST), the enzymes that detoxify a broad range of free radicals in reduced risk of inflammation, particularly in GSTM1-null women.

Furthermore, the phytochemical also increased GSTA1/2, the antioxidant enzyme in GSTM1-null/GSTT1-null men.

Taking altogether, intake of Cruciferous Vegetables regularly is associated to lower the effect of proinflammatory cytokins, particular to adult with gene GSTT1.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

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Sources
(1) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2.(PubMed)
(2) Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes by Navarro SL1, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW.(PubMed)

Saturday, 29 July 2017

Herbal Therapy: Chamomile, the Antimicrobial Whole Herb Medicine in Accelerated Wound Healing

Chamomile, exerted its biotic property in accelerated the progression of wound healing by inhibiting Pseudomonas aeruginosa, in vivo.

According to the Shiraz University of Medical Sciences, treatment of 5% C. nobile ointment extract from chamomile in rat wounds infected induced by P. aeruginosa, was more effective in expression of antibacterial and wound healing activities in comparison to tetracycline, the antibiotic medicine.

The chamomile noble, in the Pseudomonas aeruginosa biofilm formation isolated from wound infections, also showed a remarkable inhibitory concentration of 6.25-25mg/ml.

Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Dr. Kazemian H. the lead research at the joint study said, " C. nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. and "However, molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound".

Furthermore, in the testing of the effect of chamomile compounds in several models of toxicity (acute toxicity against Artemia salina and cytotoxicity against two cell lines (fibroblast and melanoma)), researchers suggested that these compounds showed low to moderate activity in all tests of acetylcholinesterase inhibitory and antibacterial activities.

And the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.

Therefore, people who intent to use chamomile for reduced risk and treatment of various diseases should be cautious to prevent overdoses' toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile) by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa by Kazemian H1, Ghafourian S1, Heidari H2, Amiri P3, Yamchi JK4, Shavalipour A3, Houri H3, Maleki A1, Sadeghifard N1.(PubMed)
(3) Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.) by Radulović NS1, Mladenović MZ, Blagojević PD, Stojanović-Radić ZZ, Ilic-Tomic T, Senerovic L, Nikodinovic-Runic J.(PubMed)

Herbal Therapy: Alfalfa, the Anti-inflammatory Natural Whole Food

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhanced digestive system, bleeding disorder, kidney and urinary tract infection, etc.
North American aboriginals have used Alfalfa seed as food in making bread and mush.

Inflammation is the natural response of immune system in regulated the production of white blood cells for protection against foreign organisms.

Alfalfa expressed significant anti-inflammatory effect through inhibited production of proinflammatory cytokins during injure, foreign invasion and free radical domino's action, etc....

According to the University of Maryland, novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem, showed significant anti-inflammatory effect against mRNA expressions of the pro-inflammatory cytokine genes, especially for IL-1β antibody.

The chloroform extract of alfalfa aerial part also is found to inhibit the function of lipopolysaccharide (LPS) of Gram-negative bacteria in stimulated immune responses in induced inflammation and suppressed LPS-mediated activation of the extracellular signal-regulated the proinflammatory and prothrombotic responses of nuclear factor kappa-B pathway.

The cinnamic acid derivatives and fatty acids active constituents of the extract have also been found to be effective in ameliorated inflammation and immune response through inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2) all involved in the development of inflammatory diseases.

Taking together, Alfalfa no doubt has processed an anti inflammatory effects by inhibited free radicals, proinflammatory cytokins and hormone involved the development of inflammatory and auto immune diseases.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem by Chen L, Liu J, Zhang Y, Dai B, An Y, Yu LL1.(PubMed)
(2) Chloroform extract of alfalfa (Medicago sativa) inhibits lipopolysaccharide-induced inflammation by downregulating ERK/NF-κB signaling and cytokine production by Choi KC1, Hwang JM, Bang SJ, Kim BT, Kim DH, Chae M, Lee SA, Choi GJ, Kim DH, Lee JC.(PubMed)
(3) Anti-Inflammatory Activities of Cinnamomum cassiaConstituents In Vitro and In Viv by Jung-Chun Liao,1 Jeng-Shyan Deng,2 Chuan-Sung Chiu,3,4(HindaWi)

Herbal Therapy: Cinnamon - The Best Whole Food Medicine for Reduced Risk and Progression of Cognitive impairment

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
Many researchers has raised a question of their's effectiveness because of quality of the herbs due to geographic differences, time of grown and harvest, etc. I do believe that these questions can only be answered by experience herbalist.

Whole herbal medicine cinnamon may be used as functional food for treatment of cognitive impairment, a renown study suggested.

According to Hoseo University, water extracts of Cinnamomum cassia Blume bark (CCB; Lauraceae), effectively prevent the cognitive dysfunction through the prevention of formation of amyloid-β in induced cell death and toxicity.

Cognitive impairment is considered as an early stage of dementia, affecting memory, language, thinking and judgment

Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Administered orally of Cinnamomum zeylanicum (CZ) for a period of 21 days in animal model induced cognitive improvement through inhibition of certain extent of oxidative stress.

In AD mice model, cinnamon reduced accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ) by inhibition of the formation of toxic Aβ oligoemers induced toxicity of Aβ on neuronal cells, thus reducing the risk of accumulation of plagues which is the early signed of AD development.

Also in animal study, the standardized lyophilized aqueous extract of cinnamon bark (LCZE) testing on learning and memory in rodents at 50, 100, and 200 mg/kg, p.o. dose levels against streptozotocin (STZ)-induced memory impairment, exhibited an improved discrimination between a familiar object and a novel object and function of neurotransmitters activity and reduced oxidative stress parameters in both brain parts.

Cinnamon and its chemical components may be beneficiary for patients in early state of Cognitive impairment. The use of the herbal medicine should be taken with care as overdoses may induce toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rat by Jain S, Sangma T, Shukla SK, Mediratta PK.(PubMed)
(2) Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats by Park S1, Kang S1, Kim DS1, Moon BR1.(PubMed)
(3) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)

Friday, 28 July 2017

Food Therapy: Kidney beans( Phaseolus), The Best Anti-Inflammatory Functional Foods

According to the University of Guelph, mices fed with red and white kidney bean display a significantly anti inflammatory effects in colitis induced by dextran sodium sulphate (DSS) exposure.

The result of anti colitis activity is attributed to the potency in reduced colon tissue protein levels through ameliorated disease severity and proinflammatory mediator expression, protected further colonic damage,.....

In biochemical approaches including reporter gene assays, immunoprecipitation, kinase assays, and immunoblot analyses, ethanol extract (Pa-EE) of Phaseolus angularis was found to exert anti inflammatory effects by suppressed the release of Prostaglandin E2 (PGE(2)) and NO in Lipopolysaccharide,..........in activation of infection and inflammation.

Furthermore, the phaseolus angularis ethanol extract (Pa-EE) strongly reduced function of ipopolysaccharide in induced the mRNA expression of formation of enzymes in response to cytokines and in production of prostaglandins involved activation of infectious and inflammatory immune response.

Orally administered Pa-EE clearly decreases the ratio of ethanol/hydrogen chloride(EtOH/HCl)-induced gastritis in mice, through protection of gastric surface tissues against further damage.

In fact, the study in differentiate the efficacy of bean hull antioxidant and anti-inflammatory activities, insisted, "Anti-inflammatory activity of bean hulls was dependent on their phenolic content and antioxidant activity that were significantly affected by cultivar and extracting solvent".

Taking together, Kidney beans (Phaseolus) and their family may be used as therapeutic functional foods in improved immunomodutory activity against inflammatory diseases.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA6.(PubMed)
(2) Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans by Yu T1, Ahn HM, Shen T, Yoon K, Jang HJ, Lee YJ, Yang HM, Kim JH, Kim C, Han MH, Cha SH, Kim TW, Kim SY, Lee J, Cho JY.(PubMed)
(3) Antioxidant and anti-inflammatory activities of bean ( Phaseolus vulgaris L.) hulls by Oomah BD1, Corbé A, Balasubramanian P.(PubMed)

Food Therapy: Cruciferous Vegetable, the Whole Food for Lower Cholesterol Absorption through Bile Acid Binding

Recent study conducted by the University of Lund, fermented brussels sprouts, one of the member of cruciferous vegetables binded the secretion of bile acids from the liver by increased 25% of the fecal dry weight.

The study also confirmed that in various vegetables (carrots, rutabagas, peas, green beans and Brussels sprouts), total excretion of bile acids was reduced only when Brussels sprouts were added.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Bile acids secreted by the liver with purpose in removing excess cholesterol in the body and aiding intestinal digestion.

Binding bile acids in gastrointestinal track is the function of preventing the reabsorption from the gut with an aim to lower the levels of cholesterol.

In vitro, the study of cruciferous vegetables also suggested that consumed regularly after steam cooking, would lower the risk of cardiovascular disease and cancer and improve public health, through lowered recirculation of bile acids resulting in utilization of cholesterol to synthesize bile acid and reduced fat absorption even more.

Dr. Kahlon TS, the lead author of the study said, " relative to cholestyramine, (a cholesterol-lowering, bileacid binding drug) in vitro bile acidbinding on dry matter basis was for the collard greens, kale, and mustard greens, 13%; broccoli, 10%; Brussels sprouts and spinach, 8%; green bell pepper, 7%; and cabbage, 5%" and (the levels of effectiveness can be classified as follow)"collardgreens = kale = mustard greens > broccoli > Brussels sprouts = spinach = green bell pepper > cabbage".

Furthermore, according to the article published in the science research, besides steam cooking showed to significantly improved bile acid binding ofgreen/leafy vegetables; sautéing also significantly improved bile acid binding of mustard greens, kale, broccoli, cabbage and green bell pepper compared with steaming, boiling or raw (uncooked).

In fact, Collard greens exhibited significantly higher bile acid binding by steaming compared with sautéing, boiling or raw in comparison to other cruciferous vegetables.

Therefore, it is safe to insist that intake of cruciferous vegetables regularly can lower the risk of cardiovascular disease and cancer, through lowering cholesterol absorption and reabsorption.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Fermentation of vegetable fiber in the intestinal tract of rats and effects on fecal bulking and bile acid excretion by Nyman M1, Schweizer TF, Tyrén S, Reimann S, Asp NG.(PubMed)
(2) Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage by Kaifhlon TS1, Chiu MC, Chapman MH.(PubMed)ch
(3) In Vitro Bile Acid Binding of Mustard Greens, Kale, Broccoli, Cabbage and Green Bell Pepper Improves with Sautéing Compared with Raw or Other Methods of Preparation by Talwinder S. Kahlon, Rebecca R. Milczarek, Mei-Chin M. Chiu(Scientific Research)

Food Therapy: Asparagus, the Natural Whole Food for Neuroprotective Effects

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Asparagus may be a potential whole food medicine for reduced risk and treatment of neuro degenerative disease, a renowned institution suggested.

Methanol extract from Asparagus cochinchinensi, in vivo and in vitro is found to exhibit neuroprotective effects through activation of the Shp-2, antibody and ErK1/2 Akt and Akt involved the cell apoptosis, cell proliferation.

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

In animal study of neurodegenerative disorders involved Alzheimer's disease (AD) , biological stresses, such as oxidative and inflammatory stress, induced neural cell damage, asparagus extract (ETAS) exerted anti neuroprotective effects, through expression of mRNAs in information transfer of DNA factors in exerted cytoprotective and anti-apoptotic functions against death of neuronal cells and early cognitive impairment.

Dr. Sakurai T, the lead researcher in the study insisted, this efficacy may be contributed by the extract in attenuated neuro-cell damage through improved hippocampus function in expression of memory.

Furthermore, other chemical compound isolated roots of Asparagus cochinchinensis may be also effective in treating cognitive impairment by ameliorated neuroinflammation through decreased production of free radical NO and suppressed microglia cells activation cause of neuronal cell death.

Taking altogether, there is no doubt that asparagus extract may be a potential agent for delay neuro degenerative disease through improved function of hippocampal regions associated with the learning and memory functions, increased neurotransmitter activity, attenuated neuro inflammatory expression and inhibited oxidative stress induced free radical in damage of neuro cells.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(2) Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice by Sakurai T, Ito T, Wakame K, Kitadate K, Arai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Fujiwara T, Akagawa K, Ishida H, Ohno H.(PubMed)
(3) Anti-neuroinflammatory constituents from Asparagus cochinchinensis by Jian R1, Zeng KW, Li J, Li N, Jiang Y, Tu P.(PubMed)
(4) Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation by Sharma K1, Bhatnagar M, Kulkarni SK.(PubMed)

Wednesday, 26 July 2017

Food Therapy: Celery, the Natural Whole Food in Ameliorated Progression and Enhanced Treatment of Gastric Ulcer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Intake of celery or supplement showed to reduce progression and treatment of gastric ulcer.

According to the King Saud University, celery [Apium graveolens L. (Apiaceae/Umbelliferae)], celery supplement at doses of 250 and 500 mg/kg body weight, enhanced the protection of gastric wall mucus (GWM), in increased stomach protection against the models used for ulcerogenesis.

Dr. Powanda MC, the lead researcher said, " Acute toxicity test revealed no deleterious or toxic symptoms or mortality over a period of 14 days. .....and (showed) a large margin of safety and "The results suggest that Apium graveolens extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, possibly through its antioxidant potential".

Celery is a species of Apium graveolens, belonging to the family Apiaceae, cultivated all around the globe as a vegetable. It can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

In support of the above analysis, celery Seed Extract (CSE), also showed to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation without induced medication interaction of enzyme systems.

Furthermore, the methanolic extract and aqueous extracts used at 300 mg kg(-1) dose, exhibited a highly significant inhibition of gastric lesions in comparison the conventional omeprazole, in dose-dependent for both aerial part of celery.

Taking altogether, intake of celery is associated to meliorate the progression and treatment of gastric ulcer, but oral of celery supplement should be taken with care.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activitie by Powanda MC, Whitehouse MW, Rainsford KD.(PubMed)
(2) Over the counter (OTC) oral remedies for arthritis and rheumatism: how effective are they? by Whitehouse MW1, Roberts MS, Brooks PM.( PubMed)
(3) Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract by Baananou S1, Bouftira I, Mahmoud A, Boukef K, Marongiu B, Boughattas NA.(PubMed)
(4) Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats by Al-Howiriny T1, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S.(PubMed)

Herbal Therapy: Andrographis paniculata, accelerated Wound Healing with Lesser Scar

Andrographis paniculata is also known as Andrographis, is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.. .....

Wound healing is a natural response to restore injured tissues.

Andrographis paniculata leaf showed to process a significant wound healing effect in restoring injured tissues, a mentioned institute suggested.

According to the Universiti Teknologi MARA, topical application of Andrographis paniculata exerted a strong effect on the rate of wound enclosure with markedly less scar width and contained large amounts of fibroblast proliferation.

In a study of wound created in four groups of rat in posterior neck region. Blank placebo applied topically to the wounds of Group 1 and Groups 2 and 3 dressed with placebo containing 5% and 10% extracts of A. paniculata, groups treated with topical showed a rate of wound healing significantly accelerated in the wound dressed compared to placebo group.

The wound healing is also increased collagen and less formation of new blood vessels with absence of inflammatory cells.

Other study, in the evaluation of the effects of andrographis wound healing activity of Swiss Wistar strain rats with either sex with topical application, 2%w/w ointment of ethanol extract and petroleum ether extract prepared in 2% w/w PEG-4000 in comparison to the left untreated control group, treatment groups showed a faster rate of complete healing in day 12 after topical application with wound contractions in petroleum ether extract, ethanolic extract were at 10.17 and 16.33, respectively.

Dr. Arnabaditya Mohanty, the lead authors in the joint study said, "Andrographis peniculata ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract".

Taking together, topical application of Andrographis paniculata leaf and extract may be used as a wound healing agent in accelerately restored injured tissues with lesser scar without induced adverse effects.

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Sources
(1) Effect of Andrographis paniculata leaf extract on wound healing in rats by Al-Bayaty FH1, Abdulla MA, Abu Hassan MI, Ali HM.(PubMed) and(University of Malaya)
(2) Preliminary Pytochemical Screening and Wound Healing Activity of Andrographis Peniculata by Arnabaditya Mohanty1 , Dusmanta Kumar Pradhan1 , Manas Ranjan Mishra1 , Jitendra Kumar Sahoo1 , Ashutosh Mishra *2, Bankim Chan(Journal of Chemical and Pharmaceutical Research)

Food Therapy: Asparagus, the Natural Whole Food for Reduced Risk and treatment of Kidney Cancers

According to the Banaras Hindu University, asparagus racemosus leaf extract inhibits growth UOK 146 renal cell carcinoma through cytotoxic activitie and downgraded the process of genes responsible for proliferation of the UOK146 cell line.

Dr. Verma SP, the lead author said, " Evidence of antiproliferative effect, PRCC-TFE3(recurrent abnormal chromosomes in gene and reciprocal gene expression) fusion transcript inhibition and static anti- or pro-apoptotic regulators(BAX0 level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation"

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia, used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Renal cell carcinoma (Kidney cancer/renal cells) is a type of kidney cancer caused by malignant cells of the limning of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

Shatavarins (containing shatavarin IV) isolated from the roots of Asparagusracemosus exerted anti cancer properties, in vivo against numbers of cancer cell lines, including A-498 (human kidney carcinoma) cell lines .

Oral administration of shatavarin to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days,, inhibited tumor cell volume and increased non-cancer cell count, through its potent cytotoxicity, compared to the untreated mice of the EAC control group.

The herbal decode also restore the normal expression of red (RBC) and white blood cell (WBC) counts and hemoglobin (Hb) concentration which are altered in patients with renal cell cancer.

There is no doubt that Asparagus has exhibited significant anticancer activity in both in vitro and in vivo experimental models but further multi and large size studies are necessary to confirm this potency.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay by Medendorp K1, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG.(PubMed)
(2) Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes by Weterman MA1, van Groningen JJ, den Hartog A, Geurts van Kessel A.(PubMed)
(3) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death by Verma SP1, Tripathi VC, Das P.(PubMed)
(4) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus by Mitra SK1, Prakash NS, Sundaram R.(PubMed)

Tuesday, 25 July 2017

Herbal Therapy: Chaste tree berry, The Whole Herb Medicine in Ameliorated Symptoms and Treatment of Premenstrual Syndrome

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

If you expect that herbal medicine will ease the symptoms of your illness immediately, you will be disappointed. Symptoms of the disease can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Chaste tree berry, the queen of all herbs may have a potency in reduced symptoms and treatment of premenstrual syndrome.

According to Dr. Döll M, the extract of chaste tree berry decreased levels of prolactin serum during the first 3 weeks of the cycle of premenstrual period, inducing stress involved expression of symptoms of PMS.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,considered as Queen herb in treating menstrual problems and discomforts and used in herbal medicine for thousands of year as anaphrodisiac agent.

Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, affecting women's physical and emotional state, and sometimes interfering with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.

In a prospective, double-blind, placebo controlled, parallel-group, multi-center clinical trial in compared VAC BNO 1095 extract and placebo for up to three cycles, conducted by the Peking Union Medical College Hospital, group treated with extract of vitex agnus castus showed a significant reduced symptoms of PMS with mean total PMSD score decreased from 29.23 at baseline (0 cycle) to 6.41 at the termination (3rd cycle) with no serious of side effects.

Furthermore, the extract of vitex agnus castus (VAC, BNO 1095) oral administrated in 67 patients enrolled and randomly assigned to receive one tablet of VAC or placebo once a day, exhibited the decreased premenstrual syndrome symptoms at the 3rd cycle, including symptoms of negative affect, water retention, food cravings and pain, in the treatment group, compared to placebo group, especially in symptoms of water retention.

The moderate-to-severe premenstrual syndrome in Chinese women study also showed a significantly greater improvement of symptoms with intake of vitex agnus castus (VAC, BNO 1095)group than placebo, including symptom of insomnia.

Taking together, Chaste tree berry may be a safe herbal medicine for treatment of PMS, through decreased levels of prolactin, negative factors and ameliorated symptoms of the syndrome in many aspects.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) [The premenstrual syndrome: effectiveness of Vitex agnus castus].[Article in German]by Döll M1.(PubMed)
(2) Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China by He Z1, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin S.(PubMed)
(3) Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus(BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Wang X.(PubMed)
(4) Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Zhang Y, Chen F, Wang X.(PubMed)

Herbal Therapy: Aloe Vera, the Natural Whole Food Medicine for Treatment of Ulcerative Colitis

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe Vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
Constipation is a condition in difficulty in emptying the bowels, in most case associated with hardened feces.

Ulcerative colitis is condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.

In a double-blind, randomized, placebo-controlled trial of 44 hospital out-patients with ulcerative colitis randomly given oral aloe vera gel or placebo, 100 mL twice daily for 4 weeks, oral administrated group showed a improvement and response occurred in nine (30%), viewed in the Simple Clinical Colitis Activity Index and histological scores.

Dr. Langmead , the lead researcher said, "Oral aloe vera taken for 4 weeks produced a clinical response more often than placebo; it also reduced the histological disease activity and appeared to be safe".

Furthermore, in the study of male Sprague Dawley rats fed experimental diets for 2 weeks before and during the induction of colitis, dietary aloe vera gel significantly ameliorated intestinal inflammatory responses in a dextran sulfate sodium (DSS) induced ulcerative colitis.

In fact, the efficacy is also found to associate to the abundant bioactivity of the herbs.

Other researchers suggested that the anti ulcerative colitis activity of aloe vera gel may be due to the healing properties of antioxidants, scavengers, chelators as well as strongly inhibited Inflammation, electrical/mechanical impairment in the gut, and a great majority of oxidative stress.

Taking altogether, herbal aloe vera may process anti ulcerative colitis properties, through expression of bioactivity in induced production of antioxidant in reduced intestinal inflammatory responses. but further study is necessary to confirm its claim.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis by Langmead L1, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS.(PubMed)
(2) Advances in treatment of ulcerative colitis with herbs: from bench to bedside by Wan P1, Chen H1, Guo Y1, Bai AP1.(PubMed)
(3) Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitismodel by Park MY1, Kwon HJ, Sung MK.(PubMed)
(4) The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis in rats by Korkina L1, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.(PubMed)

Monday, 24 July 2017

Herbal Therapy: Alfalfa, the Natural Anti Microbial Whole Food Medicine

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North American aboriginal have used Alfalfa seed as food, such as making bread and mush.

Alfalfa may be a potential anti microbial agent used for treatment of infection or infectious related diseases.

According to the Via Orabona 4, Università, chemical compound saponins found in alfalfa family exhibited anti microbial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.

Dr. Avato P, the lead author said, "(The anti micrbial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".

Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, alfalfa fed group showed a decline in fecal E. coli numbers marginally.

The study also suggested the result of decline of anti E. coli number is due to the presence of phytochemical phenolics in alfalfa.

In fact, The Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strain showed a positive effects of alfalfa seed extract in inhibition of

five bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depend on concentration of extract with the maximum inhibition was seen in 300µg/ml concentration of extract.

There is no doubt that intake of alfalfa regularly may be beneficiary in reduced risk and treatment of microbial infection and diseases. But further human trials are necessary.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech.student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)

Food Therapy: Celery, the Natural Whole Food in Suppressed Symptoms of Arthritis Diseases

According to recent study, Celery Seed Extract (CSE) has been found to be more effective in comparison to aspirin, ibuprofen, and naproxen in suppressing arthritis symptoms in a model of polyarthritis without interaction with compared medication intake.

Dr. Powanda MC, the lead researcher said, " unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems( function in interaction with medication intake) and thus is less likely to alter the metabolism of drugs the individual may be taking"

Celery is a species of Apium graveolens, belonging to the family Apiaceae, cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

The over the counter (OTC) oral remedies for arthritis and rheumatism classified celery seed extracts has a effective efficacy as ibuprofen in the anti-arthritic assay without causing gastric bleeding, but the treatment ranged is from almost zero to highly effective depending to a certain class of product.

In support of the above differentiation, A. graveolens (AGE) against liver oxidative stress in an adjuvant-induced arthritic rat model study found that oral administration of AGE (250, 500, and 1,000 mg/kg) for 24 consecutive days in the rat model, reduced symptoms of arthritis through reduced liver oxidative stress and enhanced liver antioxidant properties.

Taking altogether, intake of celery may be effective in ameliorated symptoms of arthritis through binding to the expression of proinflammation cytokins. But oral administrated large amount of celery supplements such as celery seed should be consulted with related field specialist.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activitie by Powanda MC, Whitehouse MW, Rainsford KD.(PubMed)
(2) Over the counter (OTC) oral remedies for arthritis and rheumatism: how effective are they? by Whitehouse MW1, Roberts MS, Brooks PM.( PubMed)
(3) Effects of Apium graveolens Extract on the Oxidative Stress in the Liver of Adjuvant-Induced Arthritic Rats bySukketsiri W1, Chonpathompikunlert P2, Tanasawet S3, Choosri N1, Wongtawatchai T3.(PubMed)

Sunday, 23 July 2017

Herbal Therapy: Cayenne, the Natural Whole Food Medicine for Reduced Risk of Airway Inflammation

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases, including inflammation.

Cayenne, has been used in tradition medicine for treatment of inflammation caused by invasion of microbial organisms and allergens.

Red pepper (Capsicum baccatum) extracts, according to the study by the Federal University of Rio Grande do Sul (UFRGS), exerted its anti-inflammatory properties through in inhibiting the neutrophil migration induced by carrageenan (Cg).

In animal study, the ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity through their antioxidant phenolic and flavonoid compounds against oxidative and inflammation-related pathological processes, including arway inflammation.

β-Defensin, members of the antimicrobial peptide found in cayenne inhibited the expression of the mRNA of anti-inflammatory cytokine during bacterial invasion, through stimulating immunomodulatory effects.

Other research suggested that anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory sites, such as upper airway.

Regular intake of Cayenne pepper can improve immune system against microbial infection and reduced risk of airway inflammation but overdose is found to induce toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro by Allemand A1,2, Leonardi BF1, Zimmer AR1, Moreno S3, Romão PR2, Gosmann G1.(PubMed)
(2) Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation by Spiller F1, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR.(PubMed)
(3) Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach by Zimmer AR1, Leonardi B, Miron D, Schapoval E, Oliveira JR, Gosmann G.(PubMed)
(4) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2.(PubMed)

Herbal Therapy: Andrographis, The Male Contraceptive Whole Herb Medicine?

Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......

According to the Bharathidasan University, andrographolide, a major chemical constituent of andrographis paniculata affected the process in which spermatozoa are produced from spermatogonial stem cells in the testis by interring the dividing spermatogenic cell lines.

In a 3-month-old male Wistar albino rats at two dose levels, for 48 days, rats fed with andrographolide exerted contraceptive effects by inducing decreased sperm counts, increased in-motile spermatozoa, and several possessed abnormalities.

Dr. Akbarsha MA, the lead research said, "the study points to a male reproductive toxic effect of this compound(andrographolide) when used as a therapeutic".

Unfortunately, also in male Wistar albino rats study, orally administering extract of Andrographis paniculata of 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating, treated group showed no effect on testosterone levels and fertility indices and sperm count and sperm motility when compared with the control.

Furthermore, in the comparison of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus with Valeriana officinalis and Panax ginseng, Kan Jang decode exhibited no significant negative effect of Kan Jang on male semen quality and fertility, but rather a increased number of spermatozoids in the whole ejaculate in compared to others herbal treated group.

The conflict results of above studies may be due to types of research design, small sample size and quality of herbal medicine used....., but regardless to above conclusions, large sample size and mutli centers studies are necessary to resolve these contradiction.

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Sources
(1) Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa by Akbarsha MA1, Murugaian P.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A1, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats by Allan JJ1, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)

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