Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has placed an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over the world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and pattern right to producers.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Inflammatory diseases is a disorders and conditions caused by inflammation. Cat's claw may be a next generation of medical plant for treatment of inflammation against various diseases. According to the study by the Case Western Reserve University, Uncaria tomentosa exhibited high levels of anti-inflammatory effects through interference of the pro-inflammatory expression.
In denture Stomatitis, a chronic oral disease that affects denture wearers is caused by Candida Albicans in inducing inflammation. Topical application of a gel of 2% U. tomentosa three times a day for 1 week, cat' claw significantly reduced signs of the disease, after 1 week of treatment.
In fact, the anti-inflammatory properties may also result from their ability to inhibit TNF-alpha, a central regulator of inflammation, and to a lesser production of PGE2, a principal mediator of inflammation in diseases production.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
(1) Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes by Akhtar N1, Miller MJ, Haqqi TM.(PubMed)
(2) Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils by Montserrat-de la Paz S1, Fernandez-Arche A2, de la Puerta R2, Quilez AM2, Muriana FJ3, Garcia-Gimenez MD2, Bermudez B4.(PubMed)
(3) Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark by Rojas-Duran R1, González-Aspajo G, Ruiz-Martel C, Bourdy G, Doroteo-Ortega VH, Alban-Castillo J, Robert G, Auberger P, Deharo E.(PubMed)
(4) Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report by Tay LY1, Dos Santos FA, Jorge JH.(PubMed)