Saturday, 24 June 2017

Herbal Therapy: Cat's claw, The best Whole Herb Medicine for Prevention and Treatment of Inflammatory disease

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine), linking health benefits in prevention, management and treatment of diseases has placed an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and pattern right to producers.

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Inflammatory diseases is a disorders and conditions caused by inflammation. Cat's claw may be a next generation of medical plant for treatment of inflammation against various diseases. According to the study by the Case Western Reserve University, Uncaria tomentosa exhibited high levels of anti inflammatory effects through interference of the pro inflammatory expression.

Mitraphylline (MTP), the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa, elicited an anti-inflammatory response that modulates neutrophil activation contributing to the attenuation of inflammatory episodes.

Furthermore, the ingredient, Mitraphylline (MTP) also showed a direct effect in immune system by reduced almost 40% of the production of interleukin 4 (IL-4) and inhibited around 50% of the release of interleukins.

In denture Stomatitis, a chronic oral disease that affects denture wearers is caused by Candida albican in inducing inflammation. Topical application of a gel of 2% U. tomentosa three times a day for 1 week, cat' claw significantly reduced signs of the disease, after 1 week of treatment.

In fact, the anti-inflammatory properties may also be resulted from their ability to inhibit TNFalpha, a central regulator of inflammation, and to a lesser production of PGE2, a principal mediator of inflammation in diseases production.

The effects of cat;s claw in inhibited inflammatory diseases may be resulted from its binding to proinflammatory cytokines and pathways. Use of the medical plant should be only prescribed by herbal for safety purpose.

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(1) Effect of a Herbal-Leucine mix on the IL-1╬▓-induced cartilage degradation and inflammatory gene expression in human chondrocytes by Akhtar N1, Miller MJ, Haqqi TM.(PubMed)
(2) Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils by Montserrat-de la Paz S1, Fernandez-Arche A2, de la Puerta R2, Quilez AM2, Muriana FJ3, Garcia-Gimenez MD2, Bermudez B4.(PubMed)
(3) Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark by Rojas-Duran R1, González-Aspajo G, Ruiz-Martel C, Bourdy G, Doroteo-Ortega VH, Alban-Castillo J, Robert G, Auberger P, Deharo E.(PubMed)
(4) Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report by Tay LY1, Dos Santos FA, Jorge JH.(PubMed)