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Sunday, 25 June 2017

Food Therapy: Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine), linking health benefits in prevention, management and treatment of diseases has placed an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Fresh Garlic Extract beside inhibited colon and gastric cancer in 2 previous article, it also is found to arrest the growth and alter the morphology of MCF7 breast cancer cells.

Also in MCF7 human breast cancer cells, garlic constituent diallyl trisulfide have highly effective antitumor effects by suppressesing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.

According to the study by the 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells,regardless to the state of estrogen in the tumors.

In a total of in 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and risk of breast cancer.

Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast caner cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".

Therefore, the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to existence of many phytochemicals found in the herb. Women who increased intake of garlic everyday, may see the risk of breast cancer reduced substantially.




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Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2.(PubMed)