A. Alfalfa is a flowering plant
in the genus Medicago, belonging to the family Fabaceae, It has been
cultivated all over the world as hay for cattle feeding. The leaves,
sprouts, and seeds to make medicine has been used in traditional
medicine over thousands of year to treat high cholesterol, asthma,
osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive
system, bleeding disorder, kidney and urinary tract infection, etc.
North Americal aboriginal has used Alfalfa seed as food, such as making
bread and mush.
B. Nutritional Supplements
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
13. Etc.
C. Health benefits of Alfalfa
1. Antioxidant
In
a study of measurements of pH, water holding capacity, color,
oxymyoglobin content, TBARS and oxidation-reduction potential in
evaluating the effects of a dietary protein-xanthophylls (PX)
concentrate of alfalfa
to turkey diets conducted by University of Life Sciences in Lublin,
Skromna 8, 20-704 Lublin, Poland.(1), researchers found that TBARS and
oxidation-reduction potential values suggested that the inclusion of
the concentrate to turkey diets acts as an antioxidant in the raw meat.
2. Cholesterol
In
a study to test the effect of Alfalfa used in traditional medicine to
treat high blood cholesterol conducted by Malinow MR, McLaughlin P,
Stafford C.(2), in 3 human volunteers during ingestion of diets
containing alfalfa
seeds (AS) for 3 weeks, researchers found that Plasma cholesterol
concentrations were reduced and No signs of toxicity were detected
through serum determinations of multiple parameters. The ingestion of
AS in rats decreased the concentration of plasma cholesterol, reduced
intestinal absorption of exogenous and endogenous cholesterol, and
increased fecal biliary excretion.
3. Hyperlipoproteinemia
In
a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA
(n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfa
seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged
diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(3), found that
patients with type II HLP alfalfa
treatment caused after 8 weeks a maximal lowering of pretreatment
median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P
less than 0.001) and low density lipoprotein (LDL) cholesterol from 7.69
to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of
17% and 18%, respectively. Maximal decrease was 26% in total cholesterol
and 30% in LDL cholesterol. In two patients with hypercholesterolemia
the LDL cholesterol decreased less than 5%. Apolipoprotein B decreased
in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II
HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not
change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P less than 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.
4. Disease of autoimmune
In
a study of five groups of 12-week-old female mice were per oral
treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA
(ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen
(TAM, 0.375 mg/kg BW) as the positive control, conducted by Institute
of Microbiology and Biochemistry, College of Life Science, National
Taiwan University, Taipei, Taiwan (4), researchers found that alhalfa
decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.
5. Anti-inflammatory activity
In a study of anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa
sprout ethyl acetate extract (ASEA) in ,ice coducted by College of Life
Science, National Taiwan University, Taipei, Taiwan, Republic of
China.(5), researchers found that significantly higher survival rates
than the control group and suggests that ASEA supplementation can
suppress the production of pro-inflammatory cytokines and alleviate
acute inflammatory hazards.
6. Systemic lupus erythematosus
In experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa)
is presented,conducted by Oregon Health Sciences University, Portland
(6), researchers indicate that a potential toxic and immunoregulatory
role of L-canavanine in the induction of a systemic lupus-like disease
in primates.
7. Menopause symptoms
In
a study of Eight botanical preparations that are commonly used for the
treatment of menopausal symptoms were tested for estrogenic activity,
conducted by University of Illinois at Chicago (7), researchers found
thatestrogenic components of plant extracts can be identified using
assays for estrogenic activity along with screening and identification
of the active components using ultrafiltration LC-MS. These data
suggest a potential use for some dietary supplements, ingested by human
beings, in the treatment of menopausal symptoms.
8. Neuroprotective activity
In a study of the neuroprotective effect of methanol extract of Medicago sativa
(MS, Alfalfa) on ischemia and reperfusion-induced cerebral injury in
mice, conducted by Institute of Pharmacy, Solan 173 223, India. (8)found
that suggest that treatment with MS enhances the antioxidant defense
against BCAO-induced global cerebral ischemia and exhibits
neuroprotective activity.
9. Etc
D. Side effects
1. High amount of vitamin K may reduce the effectiveness of anticogulation medicine
2. Causing additive effects for women who are under estrogen replecement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. Etc.
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(1) "Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing" by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER., posted in PubMed
(2) "Alfalfa seeds: effects on cholesterol metabolism." Posted in PubMed
(3) "Alfalfa
seeds lower low density lipoprotein cholesterol and apolipoprotein B
concentrations in patients with type II hyperlipoproteinemia", posted in
PubMed
(4) " The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice" by Hong YH, Huang CJ, Wang SC, Lin BF., posted in PubMed
(5) "Ethyl acetate extracts of alfalfa (Medicago sativa
L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro
and in vivo" by Hong YH, Chao WW, Chen ML, Lin BF., posted in PubMed
(6) "Dietary amino acid-induced systemic lupus erythematosus" by Montanaro A, Bardana EJ Jr., posted in PubMed
(7)
"Evaluation of estrogenic activity of plant extracts for the potential
treatment of menopausal symptoms" byLiu J, Burdette JE, Xu H, Gu C, van
Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH,
Farnsworth NR, Bolton JL., posted in PubMed
(8) "Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult" by Bora KS, Sharma A., posted in PubMed
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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