The pleura is a thin tissue covered by a layer of cells
(mesothelial cells) that surrounds the lungs and lines the inside of the
chest wall.
B. Pleural effusion
It is a condition of collection of fluid within the pleural cavity as a
result of heart failure, bleeding (hemothorax), infections, excessive or
decreased fluid volume, etc.
B.6. Treatments
Despite the low incidence (around 1%) of pleural effusions caused by
systemic diseases, more often connective tissue diseases, such as
rheumatoid arthritis or systemic lupus erythematosus.
Intra thoracic administration of cisplatin and sodium thiosulfate
In the study to to examine the pharmacokinetics and side effects of CDDP
of Twenty-eight patients with malignant pleural effusion received
instillation of cisplatin (CDDP) into the pleural cavity Thirteen
patients received high-dose CDDP (120 mg/m2-160 mg/m2) in combination
with sodium thiosulfate (STS), while 15 others received CDDP alone (80
mg/m2), found that malignant pleural effusion could be effectively
treated by the instillation of CDDP 80 mg/m2 into the pleural
cavity(104).
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Sources
(104) http://www.ncbi.nlm.nih.gov/pubmed/3196043
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